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The Clinical Study of Qingretongdutang on Ankylosing Spondylitis

Author: LiuXiaoBo
Tutor: SunSuPing
School: Shandong University of Traditional Chinese Medicine
Course: Chinese medical science
Keywords: ankylosing spondylitis qingretongdutang clinical study
CLC: R259
Type: Master's thesis
Year: 2011
Downloads: 30
Quote: 0
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Abstract


Objective: a specific syndrome of ankylosing spondylitis patients as test subjects to sulfasalazine as control the use of drugs, the use of the international ASAS working group to develop the ASAS20, BASDAI50 standards and efficacy of traditional Chinese medicine symptom criteria, the evaluation in order to heat and dampness, removing blood stasis collaterals to the principles of clinical experience prescriptions side Qingretongdutang treating ankylosing spondylitis patients with the clinical efficacy of stasis type.Methods: This study used a randomized, positive for drugs, parallel controlled clinical evaluation. Drug program: Chinese Test group: Treating prescription by agreement, one day, decoction 300ml, oral, morning and evening. Comparison group: oral administration of sulfasalazine, the first week: 0.25g, bid; the second week: 0.5g, bid; third week: 0.75, bid; the fourth week onwards: 1.0g, bid. Treatment for 6 months. Grouping method: According to the random number table method will be included in rate cases are grouped, in which experimental group of 30 patients in the control group of 30 patients.Clinical observation: clinical symptoms and the symptoms, Bath Ankylosing Spondylitis Metrology Index (BASMI), including cervical rotation, tragus - the wall from the other, Bath ankylosing spondylitis disease activity index survey (BADSDAI), Bath ankylosing spondylitis functional Index Questionnaire (BATHFI), clinical signs and observation points: VAS pain scores, patient overall assessment (PGA) score, physical and chemical examination: erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) (0 weeks, 6 weeks, 12 weeks , 24 weeks of the inspection time).All data are used EXCEL2007 management, data used for statistical software for analysis SPSS13.0. T tests using the measurement data, measurement data are used for all X±S (mean±standard deviation) that; count data using X2 test; level data were compared with Ridit analysis; group testing: before and after treatment showed a normal distribution is applied if the difference T test, the difference was non-normal distribution before and after treatment by rank test. Group testing: before and after treatment, the difference with the control group showed a normal distribution, if the difference between before and after treatment with t test, the difference between the treatment group and control group before and after treatment difference before and after treatment if there is non-normal distribution, the use of Wilson test. P for the two-sided test, P <0.05 was considered statistically significant.Results:Experimental group of 30 patients in the clinical recovery 0 cases, effective in 6 cases, effective in 21 cases, 3 cases, total effective rate 90.00%; control group of 30 patients in the clinical recovery system of 0 cases, effective in 1 case, effective in 16 cases, 13 cases of ineffective The total effective rate 56.67%. The Ridit analysis, total effective rate were significantly different (p <0.05), there is statistical difference was efficient (P <0.05), the experimental group than the control group. Experimental group of 30 patients reached ASAS20/BASDAI50 number of cases in 27 cases, 3 cases failed to meet the total effective rate 90.00%; control group of 30 patients achieved ASAS20/BASDAI50 number of cases in 16 cases, 14 cases failed to meet the total effective rate 53.33% . The Ridit analysis, the efficiency of the two groups were significantly different (p <0.05), experimental group than the control group.Conclusion:Qingretongdutang for ankylosing spondylitis related to stasis syndrome in patients with clinical medicine, lumbar flexion, lateral bending and other signs, BASDAI index, BASFI index, spinal pain, spinal inflammation, patient global assessment and erythrocyte sedimentation rate, C reactive indicators such as the improvement of protein function tests are better than sulfasalazine.

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CLC: > Medicine, health > Chinese Medicine > TCM Internal Medicine > Modern medicine, internal diseases
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