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The Role of ADC Measurement in Detecting Stereotactic Radiation Brain Microinjury in Rabbits

Author: MengQingYong
Tutor: YuYongQiang
School: Anhui Medical University,
Course: Medical Imaging and Nuclear Medicine
Keywords: Magnetic resonance imaging Diffusion weighted imaging Radiation injury Brain sterotactic radiosurgery
CLC: R818.7
Type: Master's thesis
Year: 2009
Downloads: 43
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Abstract


Background It is very important to give early detection and diagnosis of radiation brain injury which is one of the common complications of the radiation therapy on cranial-neck tumors. However,the imaging techniques applied in clinical now can only detect delayed radiation injury.Diffusion imaging is a well developed and noninvasive method that can be used to reflect the water molecular movement and maybe used to detect abnormality early.Objective To explore the feasibility of diffusion imaging to be used to detect early radiation injury on the basis of the microinjury model in rabbits.Materials and methods Twenty-four female Newzeland rabbits were divided into 3 groups in random according to the radiation dose given.Group with radiation dose of 20Gy,30Gy and 40Gy,there are 8 rabbits in each group.Stereotactic radiation plan was made by the treatment planning system on the basis of CT data and the right caudial nucleus was selected as the radiation target with size of 0.6cm×0.6cm×0.6cm. LINAC was used to give single large dose radiation.MR T1WI,T2WI and diffusion weighted imaging were performed before and 2,4,6,8 weeks after radiation in each group and ADC value was measured.Contrast-enhanced T1WI was performed 4 and 8 weeks after radiation.Imaging changes in each group and at different time points were compared and correlated with pathology.One-way ANOVA was used to analyse ADC values.Results In group with radiation dose of 20Gy,patchy low signal in target area was demonstrated on ADC colorful maps 2 weeks after radiation,which is obvious 4,6 and 8 weeks after. No signal change was found on T1 ,T2 ,DWI and contrast enhanced T1 weighted imaging. In group with radiation dose of 30Gy, dotty and patchy high signal in target area was demonstrated on T2WI 8 weeks after radiation.obvious hypointensity could be displayed on ADC colorful maps at different time points. No signal change was found on T1 ,DWI and contrast enhanced T1 weighted imaging.In group with radiation dose of 40Gy, dotty and patchy high signal in target area was demonstrated on T2WI 8 weeks after radiation and hyperintensity was demonstrated on DWI 4 weeks after radiation.obvious hypointensity could be displayed on ADC colorful maps at different time points. No signal change was found on T1 and contrast enhanced T1 weighted imaging.Compared with the contralateral region,ADC value decreased with great significance in all groups at different time points.The pathology indicated that cell swollen,inflammatory cell invasion in each group.In group with radiation dose of 30Gy and 40 Gy,diatation of microvessel,gliosis were also demonstrated 6 and 8 weeks after radiation.No necrosis was found in each group.Conclusion 1.It is difficult for the routine MR examination to detect radiation brain microinjury.Measurement of ADC value and ADC colorful map is sensitive to the microinjury and can help detect early and microinjury. 2.The change of ADC value is related to the radiation dose and time after radiation.Thirty Gy or more is the optimal radiation dose to induce brain microinjury and 6 weeks after is the opimal observation time point.

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