Dissertation > Excellent graduate degree dissertation topics show

The Synthesis and Characterization of Functional Magnetic Nanoparticles Used in Biomedical Applications

Author: MengQiang
Tutor: XuRenGen；FengWeiYue；QinLianJie
School: Yantai University
Course: Materials Science
Keywords: magnetic nanoparticle functionalization PVA PEG
CLC: TB383.1
Type: Master's thesis
Year: 2009
Downloads: 296
Quote: 0
Read: Download Dissertation

Abstract


The research of magnetic nanoparticles is one of the foucs in the field of biomedical nanomaterials. Magnetic nanoparticles coated by different polymers or molecules could be used in different biomedical applications such as cell separation, magnetic resonance imaging contrast enhancement, tissue repair, immunoassay, hyperthermia and drug delivery, etc. In order to synthesize the functional magnetic nanoparticles that could arrived the requairs applied in biomedical fields, we respectively modified the surface of nanoparticles by polymers, PVA and PEG, which were nontoxicity, biodegradablity, and had good water-solubility and biocompatibility. Fe3O4/PVA and Fe3O4/PEG magnetic polymer microsphere prepared were characterized by FTIR、TEM、TG、DLS、ICP-MS and VSM. The specific content in this paper are as follows:Fe3O4 magnetic nanoparticles firstly were coated by PVA via hydrogen bond. After representation, We concluded that the contents of PVA coating on the surface of magnetic nanoparticles in Fe3O4/PVA complex was 7.4%; the water-solubility of coated nanoparticles had improved; the dispersivity had increased because that the electrostatic repulsive force between particles increased after modifyed. Because the size of the Fe3O4 magnetic nanoparticles used as the magnetic core was bigger and poor distributed, the magnetic polymer microsphere gained also had larger size and the dispersibity of it didn’t arrived the prospective state. To synthesize good magnetic polymer microsphere, there must be magnetic core which has favorable properties. So we decided to make the experiment for preparing Fe3O4 magnetic nanoparticles that has small size, narrow distribution, good water-solubility and high magnetic responsive.We prepared Fe3O4 magnetic nanoparticles by coprecipitation method and the optimal concition was obtained through the orthogonal experiment. The results of characterization shew that the surface of synthetical magnetic nanoparticles adsorbed plenty of–OH functional groups which offered the nanoparticles good hydrophilcity and many surface electric charges; the particle size was uniform and the average diameter was only 11±3 nm; the hydrodynamic diameters was 168 nm and the distribution of size was narrow; Fe3O4 magnetic nanoparticles had high saturation magnetization and nearly superparamagnetic feature. In addition, the purity of nanoparticles was 99.9313% obtained by ICP-MS. Afer comparing the properties of synthetical magnetic nanoparticles with purchased, we conclued that it was successfully prepared that magnetic nanoparticles had small size, narrow distribution, good water-solubility and excellent magnetism.PEG was used as dressing agent for modified the surface of Fe3O4 magnetic nanoparticles by the method of incubation in water bath and ultrasonication in turns. The better condition was obtained through discussing the factor influenced the size of nanoparticles by DLS. It was found that PEG was combined on the surface of nanoparticles via Fe-O-Si covalent bond; coated nanoparticles had less surface electric charges but favorable dispersivity, the reason for that was discussed and analyzed by the theory about colloidal dispersion stability; the Fe content of complex was 63.467±2.82% and the purity of sample was 99.955%; VSM results shew the high saturation magnetization and better paramagnetic feature of Fe3O4/PEG nanoparticles.In short, we successfully prepared the Fe3O4 magnetic nanoparticles that had better performances. The modification of PEG improved the biocompatibility, dispersivity and water-solubility of nanoparticles. The magnetic nanoparticles protected by PEG polymer could escape the uptake of macrophage so as to prolong the time of blood circulation. It is clear that Fe3O4/PEG magnetic complex has attained the requairs for the biomedical application and can potentially used in biology separation, drug delivery and immunoassay.

Related Dissertations

  1. Study on the Mechanical Properties of Pva-high Toughness Cementitious Composites,TU528
  2. Research on Spinning Performance of Collagen and PVA Composite Solution,TQ340.64
  3. Modification for PVA-Based Composite Packaging Material with Nano-SiO2 and Its Influence on Fresh Preservation Effect of Salted Duck Eggs,TS253.46
  4. PEG-Induced Cell Fusion of Haematococccus Pluvialis and Screening of Variants,S968.49
  5. Preparation and Antioxidant Activity of Phenylethanoid Glycosides from Cistanche Salsa,R284.2
  6. Bovine serum albumin and protamine from NOCC / alginate hydrogels release : the isoelectric point of two different biological molecules controlled trial,R943
  7. Preparation and Surface Functionalization of Mg-doped ZnO Quantum Dots,O614.241
  8. Solubilizing excipients on the thermal properties of flavonoids Drug Effects,TQ463
  9. PVA film surface composition , molecular conformation and separation performance,TQ320.721
  10. Design and Implementation of PVA Process Control System Based on PCS7,TP273.5
  11. PVA fiber concrete damage evolution acoustic emission monitoring and destructive mechanism,TU528.572
  12. BC / PVA composite gel film preparation and properties of,TB383.2
  13. Study on the Performance of Bamboo Charcoal as Soil Modifier,S156.2
  14. Study on the Meltblown Process and Performance of Watersoluble Polyvinyl Alcohol,TS174.3
  15. Research on Preparing PVA Release Film and Its Related Properties,TB383.2
  16. Synthesis and Characterization of Fluorescent Magnetic Nanoparticles,TB383.1
  17. Preparation and Properties of PVA / collagen hydrolyzate / silica composite materials,TB332
  18. Theme: Study on the Esterification Reaction with Pervaporation Membrane,TQ203
  19. PVC suspension polymerization of PVA -based dispersant Development and Research,TQ325.9
  20. Preparation and Pervaporation of Methanol/methyl Acetate Mixture Through Zeolite -incorporated PVA/PVP Membrane,TQ028.8
  21. Researching and Preparation of High-Performance of M-Type Ferrite,O614.811

CLC: > Industrial Technology > General industrial technology > Materials science and engineering > Special structural materials
© 2012 www.DissertationTopic.Net  Mobile