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Optimization of Supercritical Fluid Extraction of Paeoniflorin by Using Response Surface Methodolog and Mathematical Simulation

Author: TangLei
Tutor: LiuBen
School: Zhejiang University
Course: Biochemical Engineering
Keywords: Supercritical Fluid Paeoniflorin Response Surface Methodology Step-by-step extraction mass transfer mechanism Mathematical model
CLC: TQ464.3
Type: Master's thesis
Year: 2010
Downloads: 410
Quote: 2
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Abstract


First response surface optimization method to optimize the the white peony Paeoniflorin the supercritical fluid extraction conditions, to establish the mathematical model of the supercritical fluid extraction of paeoniflorin and then according to the law of mass balance, and finally analyzed with cosolvent supercritical CO 2 the extracted mass transfer process. Box-Behnken central composite experimental design principles, on the basis of single-factor test, the three factors and three levels of response surface analysis, white peony Pieces paeoniflorin in supercritical fluid extraction quadratic polynomial mathematical model, and to paeoniflorin extraction rate of response values ??for the response surface and contour effects of extraction pressure, extraction temperature and methanol concentration on paeoniflorin supercritical fluid extraction. Paeoniflorin supercritical fluid extraction optimize process conditions: extraction pressure 18.9MPa extraction temperature was 59.9 ° C, the entrainer methanol concentration was 68.5%, entrainer flow rate of 0.4mL · min -1 , extraction time of 60 min; process conditions, the the paeoniflorin theoretical extraction rate of up to 7.85mg · g -1 . Validation experiments under the optimum conditions, the actual extraction of paeoniflorin was 7.48mg · g -1 , and compared to theoretical predictions, the relative error of about 4.71%. Supercritical fluid extraction process paeoniflorin can be drawn through the analysis of the response surface and contour extraction pressure and methanol concentration and extraction temperature and methanol concentration between the impact is more obvious, and the interaction between the extraction pressure and extraction temperature is not obvious, the methanol concentration of the entrainer very significant impact on the entire extraction process. Further seen by soxhlet extraction and ultrasonic extraction, supercritical fluid extraction, the extraction rate, the time is short, a good extraction method. Response surface experiment based on the mass transfer mechanism based on a step-by-step extraction, a mathematical model of the supercritical fluid extraction of paeoniflorin. Simulation and parametric regression model is not easily extracted solute the concentration x k = 5.243 × 10 -4 kg · kg -1 external diffusion mass transfer coefficient of the surface of the sample particles K f = 8.598 × 10 -8 m · s internal diffusion -1 and sample particles inside The mass transfer coefficient K s = 7.811 × 10 -10 m · s -1 . On model checking model can better reflect the extraction process, and provide a reference for further optimization of the model parameters and process research.

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