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Synthesis of Conformational Constrained Nucleosides via Alkyne and Azide Intramolecular 1, 3-dipolar Cycloaddition

Author: LiuXinYu
Tutor: WuJinChang
School: Jilin University
Course: Organic Chemistry
Keywords: Intramolecular 1,3 Dipolar cycloaddition Azide and alkyne The conformational restrictions nucleosides and acyclic nucleoside
CLC: O621.25
Type: Master's thesis
Year: 2010
Downloads: 210
Quote: 0
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Abstract


The conformational restrictions nucleoside research hotspots in nucleoside chemistry in recent years , many conformational restrictions nucleoside was found to have anti-viral and anti-tumor activity , at the same time be used for gene therapy is also embedded into the \in . The purpose of this paper is that the development of molecular azide and alkyne 1,3 - dipolar cycloaddition reactions involved in building triazole modified azide and alkyne 1,3 - dipolar cycloaddition reactions involved in building an effective way of the ring system , 3 ' , 5'- ring conformational restrictions nucleoside synthesis method , and the structure and conformation of the synthesis of the target product is the foundation for further study bioassay . Azide and propargyl application of this article in the first nucleoside to the introduction of the azido group and then introducing a propargyl strategy Synthesis nine deoxyribonucleoside and ribonucleoside dual modification of the cyclization precursor molecules within wide nitrogen and acetylene in the 1,3 - dipolar cycloaddition reaction of four triazole modified 3 ' , 5' - cyclic conformation restrictions deoxyribonucleoside and successfully to the conversion of 4 - carbonyl amino corresponding conformational restrictions cytidine . A detailed structural characterization of key intermediates and target product , crystallography is one of the target product , and the conformational analysis .

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CLC: > Mathematical sciences and chemical > Chemistry > Organic Chemistry > Organic Chemistry general issues > Properties of organic compounds > Chemical properties of organic reactions
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