Dissertation > Excellent graduate degree dissertation topics show

Study on Expression of Orexin Receptor 1 in Rat Pancreatic Tissue with Alimentary Obesity

Author: TianLei
Tutor: ZhaoYuYan
School: China Medical University
Course: Internal Medicine
Keywords: Obesity OX1R Pancreas Orexin 1 receptor antisense oligonucleotide
CLC: R589.2
Type: Master's thesis
Year: 2010
Downloads: 33
Quote: 0
Read: Download Dissertation

Abstract


Objective To identify high fat diet -induced obese rats pancreatic tissue in the expression pattern of increased appetite hormone receptor 1 (OX1R) , to clarify OX1R impact on body weight and metabolic indicators of nutrition obese rats and adjustment mechanism . Method to establish the high-fat diet-induced to establish nutritional obese rat model ; application of micro blood glucose measured whole blood glucose , biochemical enzymatic determination of triglycerides , chemiluminescence immunoassay method for the determination of changes in serum insulin ; Immunohistochemical identification of pancreatic tissue expression of OX1R ; obese rats intracerebroventricular infusion increased orexin receptor 1 antisense oligonucleotide (OX1R-PS-ODNs), to detect its impact on the the obese rat pancreatic tissue OX1R generated . Results After 8 weeks , the obese rats body weight , blood glucose , insulin , triglycerides, total cholesterol higher than that of the control group (p lt; 0.05). Located in the cytoplasm of pancreatic islet B cells , OX1R expression the obese group OX1R the expression levels than normal group reduced by about 16.4 % ( p lt; 0.01 ) . The obese rats intracerebroventricular infusion OXIR-PS-ODNs 72 hours , the expression of pancreatic tissue OX1R a decrease of approximately 34.1 % ( p lt; 0.01 ) . Conclusions pancreatic islet B cells expression OX1R . Hypothalamic OX system can intervene the expression of OX1R nutritional obese rat pancreatic tissue , and participate in the occurrence of obesity and blood sugar , blood lipids, serum insulin metabolic regulation .

Related Dissertations

  1. The Effect of Tanshinone ⅡA and Niacin on the Cardiovascular Function of Infant Obese Rat,R285.5
  2. A Clinical Observation on Treating Simple Obesity by Electro-acupuncture,R246.1
  3. Study on the Protein Composition of Intestinal Flora in the Antibiotics Interfered Mice and the Bacteria-related Diseases,R446.5
  4. The Effects of Aerobic Exercise Training on Oxidative Stress and Ultrastructure of Pancreatic Organization in Diabetic Rats,R587.1
  5. The Expression of Visfatin in Liver of Rats in Different Glucose Metabolic Statuses and Effects to Glucose and Energy Metabolism,R587.1
  6. Physical exercise in obese high school students time management tendencies and the impact of academic pressure,G633.96
  7. Correlation of LifeStyles and Dietary Habits with the Occurrence of Colorectal Polypus in Qingdao,R735.34
  8. Efects of Obesity on Insulin Resistance, Endothelial Function and β Cell Function,R587.1
  9. The Relationships among Osteopontin, Obesity and Insulin Resistance,R589
  10. The Synthesis of HMM and the Effect of HMM on hKv1.5 Channel and the Effect of FGF-21 on KKAy and ob/ob Diabetic Mice,R965
  11. Aerobic Dumbbell exercises for obese older women Influence of Body Composition,G804.49
  12. Study of Serum Affected the THP-1 Cell TLR4/NF-κB Signal Pathway in Obese People,R589.2
  13. Survey on Status of the Prevalence of Overweight, Obesity of Middle School Students in MILUO City and Relationship of Birth Weight and Simple Obesity,R589.2
  14. Research on Weight Loss Effect by Exercise Combined with Massage on Severe Obese Adolescents,R589
  15. Integrative Medicine Observation of 41 Cases of acute pancreatitis,R576
  16. Observation on Efficacy Maintenance Time of Catgut Implantation at Acupoint and the Acupuncture of Simple Obesity,R246
  17. STEAP4 gene in human adipocyte differentiation and regulation of the expression of factors of,R723.14
  18. 2-phase hepatic ischemia-reperfusion injury in rat pancreatic β -cell function and insulin sensitivity in peripheral tissues and the impact of the intervention effect of propofol,R657.3
  19. Research of Adipocyte Stimulated by FFA and Activate Toll-NF-KB Signal Pathway Mechanism,R589.2
  20. Study on Effects and Mechanism of Saponins of Sea Cucumber on Lipid Metabolism,R285
  21. In vitro dynamic mechanical stimulation to SD juenile former adipose cell vigor, proliferation, apoptosis and TNF - a express release impact studies,R244.1

CLC: > Medicine, health > Internal Medicine > Endocrine diseases and metabolic diseases > Metabolic diseases > Lipodystrophy
© 2012 www.DissertationTopic.Net  Mobile