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Background: Worldwide, the incidence rate of colorectal cancer (Colorectal cancer, CRC) malignancies 3. With the westernization of our diet, our CRC incidence and mortality was significantly increased in the last 30 years, the cause of death is a common malignancy 4. Of the study reported that the incidence of colorectal cancer showed a sharp upward trend after the age of 60, reached a peak after 80-year-old. With the aging of the population, the absolute value of the elderly patients with colorectal cancer is increasing. However, due to social, family, economic, physical function, and many other factors limit, a considerable portion of elderly patients with advanced stage when diagnosed and lost opportunities for radical surgery, otherwise, more than half of the patients in the recurrence and metastasis after treatment. Therefore, for older Ⅲ, Ⅳ stage colorectal cancer patients choose to both security, tolerance and efficiency of chemotherapy and attenuated efficiency of Chinese medicine therapy has become an important topic in the oncology community. Research purposes: the elderly Ⅲ, Ⅳ stage colorectal cancer as the research object, observe the role of Chinese medicine treatment improved survival, and a number of indicators affecting the survival of colorectal cancer prognosis analysis, observable Quyu detoxification method therapy, and chemotherapy combined with Synergy and Attenuation explore treatment options for elderly patients with advanced colorectal cancer. Subjects and methods: Integrative Medicine 65 cases of elderly Ⅲ accept the past five years in our hospital oncology Phase IV colorectal cancer patients were studied retrospectively, Guangdong Armed Police Corps Hospital Cancer Forsythe medical treatment of cases of the control group, observed mainly indicators survival of other indicators of progression-free survival, tumor response, changes in body weight, CEA change. The possible factors affecting prognosis, the introduction of the Cox proportional hazards model, screened on the survival of the influential factors. Results: There was a median survival of comparison, the longer the treatment group of 1000 days, 755 days of the treatment group second. The 5-year cumulative survival rates were 5.5%, 5.3%, and the difference was not statistically significant. Both groups median progression-free time in longer treatment group (225 days), Western medicine group followed (173 days), the difference was statistically significant. Cox proportional hazards regression analysis, associated with the prognosis of 14 covariates were included, including the treatment group, gender, tumor site, pathologic stage, intestinal obstruction, liver metastasis, distant lymph node metastasis, surgical procedures, chemotherapy, target Drug treatment the total symptom score before treatment the former CEA, treatment KPS score before, during chemotherapy HGB mean survival period. Results statistically significant prognostic factors: the treatment group, TCM symptom score, surgery, chemotherapy drugs, distant lymph node metastasis chemotherapy during HGB mean. Two groups of tumor response rate between treatment group, the overall response rate was 18.46 percent, 19.23 percent of the treatment group, no significant difference (P gt; 0.05); the tumor stable rate of 87.69% for the treatment group, the treatment group was 80.77%, No statistically significant difference (P gt; 0.05). The two groups of six courses of treatment, the treatment group weight gain 2.2Kg, Western medicine group fell 2.3Kg, combination therapy of Chinese and Western medicine before and after weight growth was significantly better than Western medicine treatment, statistically significant. The two groups during treatment are serious adverse medical events, hematologic toxicity, the performance of to suppress lower than that of the treatment group for the treatment group WBC, HGB Ⅱ ° above, and liver and kidney toxicity incidence is lower than the Western medicine group. Conclusion: Integrative treatment may be extended Ⅲ, Ⅳ stage generally poor elderly CRC survival time, improve survival; extension of tumor progression-free survival with greater advantage. 2. Multifactorial prognostic analysis prompted protective factors affect survival in Western medicine treatment factors, radical surgery, application Xeloda, irinotecan Kang, oxaliplatin chemotherapy, during HGB mean; risk factors for symptom score before treatment , distant lymph node metastasis. Chinese medicine treatment for elderly patients with colorectal cancer prognosis have a positive impact, and to a certain extent antagonistic toxicity of chemotherapy. The results of this study show that blood stasis and detoxification treatment of senile III by Ⅳ of colorectal cancer, prolong the median survival period, delay the time to tumor progression, Chinese medicine treatment have a positive impact on the prognosis of elderly colorectal cancer can be as senile III Ⅳ stage colorectal cancer treatment.
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