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Objective: To study warfarin and aspirin combined with non- steady-state in rats ( single dose ) and steady state ( multiple dose ) under the conditions of pharmacokinetic drug interactions, clinical rational drug use and associated provide the basis for new drug compound . Methods: The rats were divided into groups unsteady and steady group , were randomly divided into three groups, namely warfarin group (0.2mg/kg), aspirin (10mg/kg), warfarin (0.2mg / kg) aspirin group (10mg/kg), n = 6 , gavage to rats , administration of a second group of non- steady-state after multiple time points sampled , steady-state group administered continuously six days , the first day multiple time points on day 6 sampling, analysis plasma concentration time curve and pharmacokinetic parameters. Results: Compared with aspirin with a compartment model describes the data , warfarin use two-compartment model describes the data . In the non- steady state and steady state, aspirin alone and combined with the plasma concentration time curve similar pharmacokinetic parameters were not significantly different between ; in the non- steady state, warfarin alone and combined with the the plasma concentration-time curve is similar , but in steady state, the joint use of the plasma concentration-time curve is significantly higher than the curve of pharmacokinetic calculations indicate that when combined with the results , the AUC and Cmax large compared to when used alone , and there is statistical significance. Conclusion : When warfarin and aspirin combined with reach steady state, aspirin warfarin pharmacokinetic parameters affected, increasing the exposure of warfarin (AUC and Cmax). Tip two drugs when warfarin may increase bleeding tendency , when combined with drugs in clinical therapeutic drug monitoring should be noted .
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