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Preparation of Emulsion Polymerization Monolith and Its Application for the Analysis of Drug in Human Plasma

Author: ZhangQiaoXia
Tutor: YangGengLiang
School: Hebei University
Course: Pharmaceutical Analysis
Keywords: Emulsion monolithic column Solid Phase Extraction Molecularly Imprinted Between nisoldipine Nifedipine Biological samples
CLC: R96
Type: Master's thesis
Year: 2010
Downloads: 72
Quote: 0
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Abstract


High performance liquid chromatography in a dominant position in the field of drug analysis , which the central position of the column in liquid chromatography , the stationary phase of great significance and improvement . Due to the complexity of the composition of the biological sample , the protein-rich , it can not directly enter the chromatographic system , the need for biological samples appropriate pretreatment , so that the sample purification . Further, since lower concentrations of the drug in the biological fluids , it is required to further enrichment can be detected . The monolithic column line solid phase extraction can solve these problems . The paper first introduces the development status of the last few years a whole column focuses on the preparation of organic polymer monolith , structural characteristics , chemical modification , and an overview of its applications in the biological sample pretreatment . Secondly, the use of home-made emulsion polymerization monolithic column as solid phase extraction material will be applied to human plasma intermediate nisoldipine extraction , enrichment and Determination , effects of nisoldipine pharmacokinetics of the drug in mice orally within 12 h dynamics. The overall column combined with a six-way injection valve can simply switch column to remove interfering substances in biological samples macromolecules online enrichment analysis of drug . This approach solves the traditional sample preparation method is cumbersome , and required a high sample throughput , low extraction efficiency , and pollution of the environment , the kind of monolithic column for the online pretreatment blood sample can be simple , fast and efficient analysis requirements. Nifedipine as template molecule , methacrylic acid (MAA) as functional monomer emulsion polymerization method , preparation of molecularly imprinted polymer monolith . The polymer monolith as solid-phase extraction material online analytical determination of nifedipine in blood samples . The results show that the molecularly imprinted polymer monolith , with a clear molecular recognition characteristics , and the polymer extracted trace of nifedipine ability .

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CLC: > Medicine, health > Pharmacy > Pharmacology
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