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Clinical Study of Cognition Disorders with Leukoaraiosis

Author: ZhangDaWei
Tutor: XuJing
School: Dalian Medical University
Course: Neurology
Keywords: Leukoaraiosis Cognitive impairment Executive function Memory Neuropsychological tests
CLC: R749.1
Type: Master's thesis
Year: 2010
Downloads: 89
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Abstract


Objective: To investigate the different degree of leukoaraiosis (LA) patients in the cognitive function overall score and cognitive damage to a number of aspects of clinical performance. Methods: LA patients of varying degrees of 57 cases and 22 cases of healthy control group, application Montreal Cognitive Assessment (MoCA, Beijing edition) evaluation of cognitive function overall state; Digit Span WAIS-RC attention evaluation application cis-back test; auditory memory, auditory verbal learning, visual memory using nonsense figure recognition; executive function: the ability to control interference stroop the quiz interference section (C section), thinking flexibility semantic classification fluency test plan, logic capacity using the WAIS -RC Image permutation tests, concept formation and conversion capabilities using connection B (Chinese revision) test and the Digit Span Daobei quizzes, abstraction ability similarity tests of the WAIS-RC; digit symbol tests of information processing speed applications WAIS-RC , Stroop tests blocks of color part (A part) and the connection A quiz; depending spatial structure skills application WAIS-RC building block tests and clock drawing test. Results: 1. Calibration by years of education, gender and age factors, the case group and the control group, MoCA, digit symbol, digit span Daobei similarity, picture arrangement, the connection A quiz when the number of errors, even the line B test when and the number of errors, the number of errors of stroopC test, semantic fluency, clock drawing test, the building blocks of tests, auditory verbal learning immediate recall, 5min and 20min delayed recall, pictures instantly and delayed recognition and stroopA tests with The number of errors of test score differences were statistically significant (P lt; 0.05, P lt; 0.01); figures the breadth of cis back and stroopC of tests with scores difference was not statistically significant (P> 0.05). 2 according to the LA lesion patient group divided into mild and severe group compared with the control group, four groups twenty-two the the mild case group compared with the control group, only semantic fluency test score difference was statistically significant (P = lt correction; 0.05); the moderate case group compared with the control group MoCA, digit symbol, digit span Daobei similarities, picture arrangement, to connect the A and B tests with semantic fluency building blocks quiz Auditory Verbal Learning immediate recall of tests score difference was statistically significant (corrected P value lt; 0.05); severe case group in addition to the above-mentioned exception, the number of errors, the clock drawing test connection A and B tests error the number, stroopA stroopC of tests, pictures instantly and delayed recognition test score difference was statistically significant (corrected P value lt; 0.05). 3. Mild case group with the moderate case group and moderate cases of severe cases, the number of errors compare stroopC quiz results with a significant difference (corrected P value lt; 0.05). Conclusion: 1.LA the overall level of cognitive function in patients with decreased auditory memory, visual memory, the ability to control interference, flexibility of thinking, planning and logic ability, concept formation and conversion capabilities, abstraction capabilities, information processing speed, The visuospatial feel multifaceted cognitive disabilities. 2. Mild LA patients have demonstrated the flexibility of thinking to reduce a wide range of cognitive dysfunction the LA condition reached moderate performance are obstacles to sleep for memory, executive function, information processing speed and visuospatial cognitive function overall state of decline. Executive function damage 3.LA patients with the disease progress and heavier, the performance decline in patients with mild LA thinking flexibility, patients with moderate LA plan and logical ability, concept formation and conversion capacity, abstraction ability has also decreased severe the the LA patients of interference The ability to control also impaired. 4.LA patient's attention is relatively intact.

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CLC: > Medicine, health > Neurology and psychiatry > Psychiatry > Cerebral organic mental disorder
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