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Expression and Clinical Significance of TGF-β1 and Tenascin in the Brain Galotinous Tumour

Author: LengWen
Tutor: WangHuaXin
School: Dalian Medical University
Course: Pathology and Pathophysiology
Keywords: TGF-β1 Tenascin Glioma Degree of malignancy Attack
CLC: R739.4
Type: Master's thesis
Year: 2010
Downloads: 40
Quote: 1
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Abstract


Objective: (1) to explore the expression of TGF-β1 in human glioma cells , relationship analysis with glioma malignancy and development . ( 2) to investigate the expression of Tenascin of in human glioma cells , and analysis of the relationship with glioma malignancy and development . (3 ) to explore the synergy between TGF-βl Tenascin . Methods : The expression levels of TGF-β1 and Tenascin detected by immunohistochemical method in 50 cases of glioma specimens , TGF-β1 and Tenascin expression in glioma cytoplasm and peripheral and with brain glue The stromal tumors vicious were positively correlated. Conclusions : (1) TGF-β1 expression in glioma cell proliferation activity and histological grade is closely related to glioma as an evaluation of the degree of malignancy , invasion and prognostic indicators . (2) Tenascin is highly expressed in malignant glioma prove Tenascin may be involved in glioma invasion and promote the growth of glioma invasiveness . (3) TGF-β1 and Tenascin common expression in gliomas , and expression increased with tumor malignant progression , suggesting that their interaction is the molecular basis of glioma cell proliferation and invasive growth .

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