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Collagenase (collagenase) chemical dissolution technique is an effective method for the treatment of lumbar disc herniation (Lumbar disc heniation LDH) displayed by the large number of domestic and international basic and clinical research, many hospitals to carry out this technology. Ozone (O3) is one of the strongest oxidant known, the last decade, some Western European countries, the use of ozone treatment of lumbar disc herniation achieved good clinical results, since 2000 the country have also developed this technology and proved useful clinical and practical value. In recent years, the clinical carried out ozone collagenase injection therapy LDH, and have achieved good results. But the lack of a unified clinical, objective indicators used to predict the the LDH patients collagenase intervention in patients with. We propose to quantify the hardness of the herniated disc, CT values ??are forecast CT-guided target injection collagenase dissolved O3 disc surgery curative effect. Objective: This study aimed to investigate the relationship between the CT value and efficacy of CT-guided collagenase injection target joint O3 the intervertebral disc Chemonucleolysis in prominence and CT values ??guide the target injection of collagenase as a predictor of CT United O3 disc dissolved postoperative the feasibility of the objective indicators of the efficacy. Methods: A retrospective study of cases admitted from June 2008 to June 2009 100 cases, including 53 males and 47 females. Aged 18 to 65 years, mean age of 54.2 years. Duration of 1 month to 15 years, L4 5 disc herniation 45 cases, l5 to Sl disc herniation 55 cases. Accept the target CT-guided injection of collagenase O3 disc dissolution treatment of patients based on CT value and efficacy of box-type diagram is divided into CT value ≤ 90 group (60 cases) and CT value gt; 90 group (40 cases). Puncture under CT guidance, based on CT images prominence as the \The application of modified Macnab evaluation standard patients were followed up after three months and six months respectively. Results: All patients all at once successful puncture. CT value and efficacy of collagenase for the treatment of lumbar disc herniation, CT The smaller the value, the better the treatment effect. The efficacy of gender, age, weight, duration and disc gap with collagenase for the treatment of lumbar disc herniation no correlation. After 3 months follow-up, 100 patients received collagenase after interventional treatment, good rate of 67.0%, total effective rate (excellent may be) of 79.0%. CT value ≤ 90 groups: excellent in 28 cases, good in 23 cases, 6 cases and poor in 3 cases, good rate of 85.0%, efficiency 95.0%; CT value gt; 90: excellent in 4 cases, good in 7 cases, 9 cases poor in 20 cases, good rate of 27.5%, 50.0% efficiency. After 6 months follow-up, the excellent and good rate of 79.0%, total effective rate (excellent may be) of 91.7%. CT value ≤ 90 groups: excellent in 32 cases, good in 23 cases, 3 cases and poor in 2 cases, good rate of 91.7%, efficiency of 96.7%, CT value gt; 90: excellent in 5 cases, good in 7 cases, 9 cases poor in 19 cases, good rate of 30.0%, 52.5% efficiency. After 3 months follow-up two sets of comparison OR = 0.175, P = 0.000, after 6 months follow-up two comparison OR = 0.039, P = 0.000, between the two groups were significantly different CT value ≤ 90 group more effective than CT value gt; 90 group. Conclusion: 1 CT-guided Joint O3 the intervertebral disc Chemonucleolysis in the target injection of collagenase, the CT values ??of the projections and efficacy was negatively correlated CT value relatively better patient outcomes. CT value of high and low projections can be used as to predict the joint O3 disc objective index of dissolved curative effect of CT-guided target injection of collagenase.
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