Dissertation > Excellent graduate degree dissertation topics show

Efficacy Evaluation of Helicobacter Pylori with Ten-day Sequential Therapy and Standard Triple-drug Therapy

Author: MengXiaoLing
Tutor: HuoLiJuan
School: Shanxi Medical
Course: Digestion within the science
Keywords: Sequential therapy Helicobacter pylori Eradication rate
CLC: R57
Type: Master's thesis
Year: 2010
Downloads: 63
Quote: 0
Read: Download Dissertation

Abstract


Backgroud:Helicobacter pylori(H.pylori, HP)is closely related to the prevention of the disease of Chronic gastritis, Peptic ulcer, Gastric cancer and Gastric mucosa-associated lymphoid tissue lymphoma. Eradication of HP has important clinical significance. With the widespread use of antibiotics, HP resistance to conventional therapy significantly increased the urgent clinical need for a program to improve the eradication rate of HP. The sequential therapy (PPI+amoxicillin for 5 days, followed by PPI+clarithromycin+tinidazole for next 5 days) which was proposed in 2002 by the Italian scholar can improve the eradication rate of HP (89%vs77%) more significantly than the standard triple therapy. But now most of the data of the sequential therapy is from the HP infection in high southern Europe region. China needs to further sequential therapy in clinical validation.Objective:To determine whether the sequential therapy is better than the standard triple-drug therapy in treatment of H pylori infection for adults.Methods:Ninety-seven patients with H pylori positive were randomly divided two groups. Forty-five patients received a 10-day sequential therapy [esomeprazole (20 mg, twice daily) plus amoxicillin and clavulante potassium (685.5mg,twice daily) for the first 5 days, followed by esomeprazole (20mg,twice daily), clarithromycin (500 mg, twice) and tinidazole (500mg,twice) for the remaining 5 days].Fifty-two patients received a 10-day triple therapy [esomeprazole (20 mg), amoxicillin and clavulante potassium (685.5mg,twice daily) and clarithromycin (500 mg),twice daily].H pylori eradication was checked four weeks after treatment using 14C-urea breath test.Results:97 patients with H. pylori infection were included in our study.91 patients completed in the whole trial,patients were lost in the follow-up(3 patients received the 10-day sequential therapy and 3 patients received the 10-day triple therapy).The eradication rate of the 10-day sequential therapy group was 91.1%(intention-to-treat, ITT) and 90.5%(per-protocol analysis, PP).The standard triple-drug therapy group was 82.7%(ITT) and 81.5%(PP).There was not significiant difference between two groups(P=0.225 ITT, P=0.229 PP).6 patients had side-effects, the sequential-therapy group 3 patients(diarrhea 1 patient, dysgeusia 1 patient and anorexia 1 patient),the standard-triple-drug-therapy group 3 patients(nausea/vomiting 1 patient, diarrhea 1 patient and headache 1 patient). Side-effects rate between the sequential-therapy group and the standard-triple-drug-therapy group were 6.67%and 5.55%,respectively,the difference was no statistic meaning(P>0.05). All side-effects disappeared in the end of treatment and did not affect the treatment.Conclusions:The 10-day sequential therapy achieves a higher eradication rate than the 10-day standard triple-drug therapy in adults, but the difference was no statistic meaning. However, from the cost-effectiveness point of view, the 10-day sequential therapy is more economical than the standard triple therapy for 10 days.

Related Dissertations

  1. Epidemiology of Helicobacter Pylori Infection and Associated Factors among Workers in Dalian Port Group,R181.3
  2. Helicobacter pylori infection on common complication of cirrhosis risk of,R575.2
  3. Expression of hPOT1、p53 and Their Relationship with HP Infection in Gastric Carcinoma,R735.2
  4. Relationship between Helicobacter Pylori Infection and Type 2 Diabetes Mellitus,R587.1
  5. Furazolidone-based Triple Therapy for Helicobacter Pylori: A Clinical Analysis of 108 Cases,R57
  6. The Changes of Serum Levels of Ghrelin and IGF-1 in Idiopathic Short Stature Children and Their Relationship with Helicobacter Pylori Infection,R723
  7. The Efficacy and Cost-effectiveness Analysis of the Rescue Therapy for Treament Failure of Helicobacter Pylori Infection,R57
  8. Antibiotic-resistance of Helicobacter Pylori and Effects of Helicobacter Pylori Eradication on Different Subtypes of Functional Dyspepsia,R57
  9. Kunming Children Helicobacter pylori infection and risk factors,R725.7
  10. Helipcobacter Pylori Infection and Clinical Significance of Idiopathic Tonsillar Hypertrophy in Preschool Children,R766
  11. Follow-up Studies of 140 Gastric Mucosal Epithelial Dysplasia Patients,R735.2
  12. Role of Helicobacter Pylori cheA Gene in Chemotaxis in Vitro and Colonization in Vivo,R392
  13. Screening and Identification of B-Cell Epitopes in Urease B Subunit of Helicobacter Pylori,R392
  14. Eradication of Helicobacter pylori in children with chronic idiopathic thrombocytopenic purpura Efficacy,R725.5
  15. An Investigation of Helicobacter Pylori Infection in Children with Idiopathic Thrombocytopenic Purpura,R725.5
  16. Helicobacter pylori infection and the Xinjiang region of primary gastric lymphoma Correlation,R735.2
  17. The same individual serum and comparative study of Helicobacter pylori infection in GCA,R735.2
  18. Interaction of Helicobacter Pylori with MDM2 SNP309 Polymorphisms and Susceptibility to Gastric Cancer Studies,R735.2
  19. Expression and Immunoreactivity Analysis of Hspa Gene from Helicobacter Pylori in Lactococcus Lactis,R378.3
  20. The Influence of Blocking Tim-3 Signal Pathway on Immune Pathopoiesis of H.pylori Infection and Immune Protection of H.pylori Vaccine and It’s Mechanisms,R392
  21. Preparation of Chitosan Nanoparticle Loaded with Helicobacter Pylori Lpp20 and Primary Study of Its Mucosal Vaccination in Mice,R392

CLC: > Medicine, health > Internal Medicine > Digestive and abdominal diseases
© 2012 www.DissertationTopic.Net  Mobile