Dissertation > Excellent graduate degree dissertation topics show

Research on Lymphatic Vessel Density and the Expression of Endothelial Vascular Growth Factor-D in Bladder Transitional Cell Carcinoma

Author: JiangFeng
Tutor: ChenHeQun
School: Central South University
Course: Department of Urology
Keywords: BTCC VEGF-D Lymphatic vessel density prognosis
CLC: R737.14
Type: Master's thesis
Year: 2007
Downloads: 21
Quote: 0
Read: Download Dissertation

Abstract


OBJECTIVE:1)To investigate expression and clinical significance of VEGF-D in Bladder Transitional Cell Carcinom.2)To determine tumoral lymphatic vessel density(LVD)in BTCC and its correlation with clinical findings.3)To evaluate the relationship of the expression of VEGF-D and LVD.METHOD:1)We assessed the expression of VEGF-D by immunohistochemistry in 50 Bladder Transitional Cell Carcinomas.The relationship VEGF-D expression and established clinicopathological parameters was assessed.2)Lymphatic vessels was immunostained with D2-40 and LVD evaluated in tumoral areas.We assessed the relationship LVD and established clinicopathological parameters.3)To analyze the relationship of the expression of VEGF-D and LVD.RESULTS:1)VEGF-D expression was identified in 42 cases(84%)with in immunohistochemistry.Higher expression of VEGF-D was significantly correlated with poor histologic grade,clinical stage and tumor size (P＜0.05).2)The LVD was significantly higher in stromal tissue of tumors than in that of normal tissues(P＜0.001).LVD was significantly higher in high-grade tumors than that in low-grade tumors(P＜0.05).LVD was not associated with pT stage and tumor size(P＞0.05).3)The level of VEGF-D expression significantly correlates with LVD(P＜0.05).CONCLUSIONS:1)There was significant correlation between the level of VEGF-D expression and tumor grade,tumor size and pT stage of patients with BTCC.it may be a novel prognostic factor in BTCC2)LVD was significantly associated with tumor grade of patients with BTCC,not with pT stage.3)VEGF-D may be a useful decision-making biomarker for the treatment of BTCC.Anti-VEGF-D and anti-lymphangiogenic treatment may be new and effective therapy against BTCC.

Related Dissertations

  1. The Value of Ultrasonic Elastography in the Diagnosis and Prognosis of Breast Lesions,R445.1
  2. Effects of Angiopoietin-1 on Vascular Angiogenesis Regulator Factor in Human Umbilical Vein Endothelial Cells Cultured with High Glucose,R587.2
  3. The Study of Clinical Prognostic Factors in Nasopharyngeal Carcinoma after Intensity Modulated Radiation Therapy,R739.63
  4. Effects of the Applied External Weak Steady Direct Current Electrical Fields on Diastolic Function after Balloon Injury in the Rabbit Abdominal Aorta,R541.4
  5. The Relationship between TLR4 Protein Expression of Peripheral Blood Monocytes and the Pathogenetic Condition and Prognosis in Patients with Acute Coronary Syndrome,R541.4
  6. Clinical Analysis of 11 Cases of Primary Breast Lymphoma,R737.9
  7. Recurrent Ovarian Cancer Surgery Again with Surial Analysis of Relevant Factors,R737.31
  8. Multiple Primary Colorectal Cancer Diagnosis and Surgical Treatment,R735.3
  9. Clinical Analysis of Postoperative Recurrent-metastatic Gastrointestinal Stromal Tumors,R735
  10. Color Doppler to Determine Perinatal Outcome of Clinical Value,R714.7
  11. A Study on the Coma Scales and Electroencephalogram for the Prediction of the Comatose Patient,R741.044
  12. The Affection and Correlation of VEGF、 SDF-1 to the Homing of Bone Marrow Hemopoietic Stem Cells in Myocardial Infraction Area,R542.22
  13. The Study of Correlation between Left Atrium Scar Area with Radiofrequency Ablation Destination and Prognosis in Persistent Atrial Fibrillation Patient,R541.75
  14. A Study of the Expressions of MT1FmRNA and VEGFmRNA in Acute Myelocytic Leukemia,R733.71
  15. Exploration of the Risk Factors and Assessment on the Clinical Staging Systems of Patients with Multiple Myeloma,R733.3
  16. Research of Risk Factors, Predictors and Prevention of Pancreatic Fistula after Pancreatoduodenectomy,R656
  17. The Feasibility of the Immunohistochemistry Classification to Predicting Prognosis in Breast Cancer,R737.9
  18. Expression and Implication of Cripto-1、 E-cadherin、 β-catenin and vimentin in Ovarian Serous Adenocarcinoma,R737.31
  19. Cervical Cancer Patients Clinical Prognostic Factor Analysis (72 Cases Analysis Attached),R737.33
  20. Expression of NRP-2 and VEGF in Colorectal Adenocarcinoma and Colorectal Adenoma Tissues,R735.34
  21. Establishment and Study of the Cultured Model of Microencapsulated Human Gastric Carcinoma Cells,R735.2

CLC: > Medicine, health > Oncology > Genitourinary tumors > Urinary tumors > Bladder tumor
© 2012 www.DissertationTopic.Net  Mobile