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Study on Erythrocyte Immune Adhesion Function and Expression of CD58 and Effects of Lumbrukinase in Patients with Chronic Renal Failure

Author: DuShanShan
Tutor: ChenShiJian
School: Nanchang University
Course: Internal Medicine
Keywords: Chronic renal failure Red blood cell adhesion function CD58 Lumbrokinase
CLC: R692.5
Type: Master's thesis
Year: 2008
Downloads: 53
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Abstract

I. PURPOSE: To investigate the expression and its relationship with creatinine clearance in patients with chronic renal failure the red blood cell adhesion function and red blood cell membrane immune molecules CD58 (lymphocyte function-associated antigen 3, LFA-3); erythrocyte immune function between different causes of group similarities and differences; Chinese medicine lumbrokinase on erythrocyte immunity and CD58 expression in patients with chronic renal failure, to clear lumbrokinase whether erythrocyte immune regulatory function. Method: Select 34 patients with chronic renal failure, before and after treatment give lumbrokinase enteric-coated capsules were used to detect serum creatinine and translation of the creatinine clearance, and yeast adhesion test the determination of red blood cell C3b receptor rosette rate (RBC-C3bRR) , red blood cell immune complex rosette (RBC-ICRR), red blood cell C3b receptor promote inhibition rate of flow cytometry to determine the expression levels of CD58 molecules; 35 normal control group was measured in the same manner as the above indicators. Results: ARF group compared with the control group before and after taking lumbrokinase the RBC-C3bRR, to promote the rate of CD58 were significantly decreased RBC-ICRR and the inhibition rate was significantly higher (P <0.05). ARF group compared with before taking the medication, of RBC-C3bRR and promote the rate of the rise, RBC-ICRR and inhibition rate downward trend (P <0.05); CD58 was no significant difference (P = 0.123), medication before and after the creatinine clearance was no significant difference (P = 0.405). The RBC-C3bRR promote rate CD58 molecule creatinine clearance was some positive correlation, the correlation coefficient (r) was 0.618 (P = 0.001), 0.491 (P = 0.004), 0.460 (P = 0.004); inhibition rate The creatinine clearance rate was a negative correlation, the correlation coefficient was -0.502 (P = 0.001); RBC-ICRR with creatinine clearance less correlated, the correlation coefficient was -0.286 (P = 0.030). Renal failure patients divided into three groups according to etiology: the nephritis group of 13 patients, diabetic nephropathy in 10 cases, 9 cases of hypertensive nephropathy, glomerulonephritis lower rate than the other two groups of RBC-C3bRR and promote, and inhibition of RBC-ICRR rates were higher (P <0.05); between diabetic nephropathy, hypertensive nephrosclerosis group 4 showed no significant difference (P> 0.05); CD58 there was no significant difference among the three groups (P> 0.05). Conclusion: CRF patients erythrocyte immunity and CD58 expression than normal reduced. CRF patients after eight weeks of taking lumbrokinase adhesion function improved, but not significantly increased creatinine clearance and CD58 expression compared with normal immune function continued to show a lower status. With the decline in creatinine clearance, erythrocyte immune function and CD58 were tested for damage. Renal failure stage due to different causes, immune function also makes a difference, nephritis due to renal failure, renal failure due to its erythrocyte immunity worse than diabetic nephropathy and hypertensive nephropathy, CD58 difference between the three kinds of etiology obvious.

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