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The Experimental Study of Sutureless and Stentless Heterogeneity Aorta Biovalve

Author: CaoYanFei
Tutor: ChenLong；ChenZuoSheng
School: Fujian Medical
Course: Cardiothoracic Surgery
Keywords: Non - sew-up Stentless Xenograft aortic bioprosthesis pulsatile flow experiments
CLC: R654.2
Type: Master's thesis
Year: 2008
Downloads: 18
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Abstract


Stentless aortic bioprosthesis for laminar flow, the blood flow through the valve orifice EOA small MTPG, is particularly suitable for elderly patients with small aortic valve ring, has been more and more widely been cardiac surgery Doctors are accepted. Stentless aortic valve complex suturing technique presents a number of drawbacks, mainly operative and aortic clamping time, a high degree of difficulty of surgical techniques, suture improper cause valvular deformation resulting in poor closed valve leaflets, causing valvular regurgitation or flap week drain the occurrence. Therefore, we developed a new type of non-suture stentless xenograft aortic bioprosthesis; conducted a preliminary study of its valvular function in vitro the late valve in vivo study to provide the basis. Objective: to develop a new type of non-suture stentless xenograft aortic bioprosthesis; 2. In vitro its valve function and coronary flow in a preliminary study and observation; research methods: 1. Choose NiTi shape memory alloy as scaffolds, by weaving or carving, made of phase transition temperature is 34-42 ℃ bracket. Cut fresh porcine aortic valve suture to the bracket with 7-0 sutures after anti-calcification treatment, and in the preparation of a good valve outer covering medical Dacron cloth bag. By liquid nitrogen, and stored. ; Build a heart model in isolated heart built into the new valve, closed the naked eye and the heart of color Doppler ultrasound observations valve, coronary blood flow and paravalvular leak situation; 4 TH-1200-type artificial heart valves # 25 new valves and clinical commonly used mechanical heart valve in vitro pulsatile flow the laboratory bench detection homemade the average MTPG, effective orifice area and regurgitation percentage; Results: 1 non-suture stentless xenograft aortic bioprosthesis design and production methods to the technical requirements of the prosthetic valve. 2 new valve implantation process is simple, and can simplify the surgical procedure to reduce the difficulty of operation, and to complete the removal of diseased valve and the naked eye and echocardiography under observation prompted valve closed tightly, no obvious paravalvular leakage and coronary flow. Homemade # 25 new valve in the simulation of cardiac output (CO) 3L the 4L and 5L/min conditions under average test the MTPG (4.215 ± 0.220) (5.168 ± 0.367) (6.158 ± 0.487) mmHg, effective orifice area (1.998 ± 0.186) (2.325 ± 0.387) (3.184 ± 0.241) the cm2 and regurgitation percentage (5.331 ± 0.284) (4.984 ± 0.521) (360.9 ± 0.264)% in line with national standards. Conclusions: the the bioprosthesis excellent blood flow dynamics transvalvular pressure on the small without anticoagulant advantages, and to simplify the surgical procedure to reduce the difficulty of operation; 2. Novel non-suture stentless xenograft aortic bioprosthesis mean transvalvular pressure gradient, the effective opening area and regurgitation percentage in line with national standards better overall performance than the commonly used clinical mechanical valve; this dissertation research work funded Fujian Provincial Department of Science and Technology Fund (2007J0109)

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CLC: > Medicine, health > Surgery > Of surgery > Cardiovascular and lymphatic system surgery > Heart
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