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Objective To study the gallbladder adenocarcinoma, cancer tissue, adenomatous polyps and chronic cholecystitis in four kinds of DNA damage repair proteins (among Expression of ERCC 1 , MGMT, hMSH 2 hMLH 1 ) expression and its clinical pathological significance. Methods 108 patients with gallbladder adenocarcinoma 46 cases paracancerous organizations, 15 cases of adenomatous polyps and 35 patients with chronic cholecystitis surgical resection specimens routinely paraffin-embedded sections among Expression of ERCC 1 , MGMT, hMSH 2 , and hMLH 1 staining methods are EnVision TM immunohistochemical method. 1, gallbladder adenocarcinoma among Expression of ERCC 1 , MGMT, hMSH 2 and hMLH 1 positive expression rate (48.2%, 57.4%, 50.0%, 49.1%) and its score (2.4 ± 1.3,2.5 ± 1.8,2.2 ± 1.9,2.2 ± 1.8) were significantly lower than the adjacent tissues (positive rate: 87.0%, 87.0%, 84.8%, 87.0%; Rating: 4.6 ± 1.1,4.5 ± 1.2,3.9 ± 1.3,4.2 ± 1.2), adenomatous polyps (positive rate: 86.7%, 86.7%, 80.0%, 86.7%; rating: 4.8 ± 1.2,4.6 ± 1.1,3.7 ± 1.3 4.0 ± 1.1) and chronic cholecystitis (positive rate: 94.3%, 94.3%, 88.6%, 88.6%; ratings: 5.2 ± 1.0,4.8 ± 0.9,4.1 ± 1.1,3.9 ± 1.1) were significant or highly significant difference (P <0.05 or P <0.01); different types of benign lesions in DNA damage repair protein expression positive rates and scores were no significant differences (P> 0.05). Among Expression of ERCC 1 , MGMT, hMSH 2 and (or) hMLH 1 express negative benign gallbladder epithelium showed moderate to severe atypical The hyperplasia pathomorphological performance. 3, adenoma or well-differentiated adenocarcinoma, maximal diameter of mass <2cm, lymph node metastasis, and does not infringe the surrounding tissue cases among Expression of ERCC 1 , MGMT, hMSH 2 and hMLH 1 expression positive rates and scores were significantly higher than poorly differentiated adenocarcinoma, maximal diameter of mass ≥ 2, lymph node metastasis, and cases of violations of the surrounding tissue (P <0.05 or P <0.01); 4 kinds of DNA damage repair protein expression associated with sex, age and the presence of gallbladder stones had no significant relationship (P> 0.05). Conclusion 4 kinds of DNA damage repair protein expression levels are reflected gallbladder adenocarcinoma, progression, clinical biological behavior and an important prognostic marker to detect the expression levels may have important clinical value in guiding gallbladder cancer clinical chemotherapy; detection of benign lesions four kinds of DNA damage repair protein expression levels of prevention and early detection gallbladder may have some clinical significance.
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