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Objective: Impaired Glucose Tolerance (IGT) and type 2 diabetes (T2DM) patients with insulin resistance (IR) as the center of a variety of metabolic disorders: abnormal hyperinsulinemia, insulin resistance, blood glucose and lipid levels. IR is a typical characteristic of the type 2 diabetic patients, the persistence of IGT and T2DM stage. Vascular complications of diabetes (DVD) is the leading cause of death in patients with T2DM, and the function of vascular endothelial cell injury and dysfunction is one of the important factors of DM vascular disease, early detection and identification of vascular endothelial function (FVE) exception is the prevention and treatment of type 2 diabetic vascular complications an important measure. Hepatocyte growth factor (HGF) is a multifunctional cytokine, can stimulate cell proliferation, differentiation, migration, to promote the damage tissue repair, angiogenesis, mitogenic effect on vascular endothelial cells and anti-apoptotic effects, is a species-specific endothelial cell growth factor, damage repair is also a factor. Recent studies have found: HGF level in T2DM, atherosclerosis hardening (AC) disease, hypertension, myocardial infarction, congestive heart failure, abnormal expression. Detection IGT patients, patients with type 2 diabetes mellitus (DM-CHD) and type 2 diabetes mellitus patients with coronary heart disease (DM CHD) HGF levels, to explore the correlation between serum HGF levels in type 2 diabetic cardiovascular complications, as well as with the relevant analysis of the factors discussed HGF patients with T2DM FVE. Methods: (1) packet IGT group: Select impaired glucose tolerance in 30 patients; DM-CHD group: 30 cases of patients with type 2 diabetes: DM CHD group is selected: Select 30 cases of type 2 diabetes mellitus in patients with coronary heart disease; NC group: select normal physical examination in 30 cases as a control. (2) parameters were measured systolic blood pressure (SBP), diastolic blood pressure (DBP), body mass index (BMI), waist circumference (W), fasting plasma glucose (FPG), 2h glucose (2hPG), fasting insulin (INS), glycosylated hemoglobin were measured (HbA1c), total cholesterol (TC), triglyceride (TG), aspartate aminotransferase (ACT), alanine aminotransferase (ALT), uric acid (UA), blood urea nitrogen (BUN), creatinine ( Cr), ELISA double antibody sandwich quantitative determination of the level of serum HGF. (3) statistical methods results are expressed as mean ± standard deviation ((?) ± S) said that the groups were compared using analysis of variance, correlation between the serum hepatocyte growth factor (HGF) and each index using linear regression, multiple regression. Results: (1) the IGT group, DM-CHD group, the DM CHD group and NC group SBP, DBP, FPG 2hPG, INS, HbA1c, ACT, HGF differences are significant, statistically significant (p less than 0.05 ). (2) serum HGF in the IGT group (412.02 ± 101.96) pg / ml, DM-CHD group (422.71 ± 126.77) pg / ml, DM CHD group (638.88 ± 167.90) pg / ml were higher than NC group, the difference was significant , statistically significant (p <0.05). Serum HGF in DM CHD group than IGT group and DM-CHD group, there was significant difference was statistically significant (p <0.05); DM-CHD group and IGT group, the difference was not significant (p> 0.05). (3) Correlation analysis showed that: the level of serum HGF with FPG was positively correlated (r = 0.366, p <0.05). The serum HGF as the dependent variable, SBP, DBP, FPG, 2hPG, INS, HbAlc, ACT as independent variables, multiple regression analysis, the serum HGF DBP is highly correlated (r to 2 = 6.125, p <0.05) Conclusion : (1) HGF levels in IGT and DM-CHD by significantly higher in the DM CHD by increased more significant, the level of serum HGF as a reflection of one of the indicators of the type 2 diabetic cardiovascular disease severity. (2) elevated serum HGF IGT stage i.e., reflecting the FVE function already exists in the IGT stage exception. (3) the level of serum HGF DBP, FPG, and other related factors.
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