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Objective: To investigate the clinical features of solitary pulmonary nodules (solitary pulmonary nodule, SPN), CT, PET / CT, fiber bronchoscopy, the role of percutaneous lung biopsy for the diagnosis of SPN and VATS (video-assisted thoracoscopic surgery, VATS) in the of SPN diagnosis and treatment. Methods: Shandong Provincial Hospital from September 2005 to December 2007 95 patients hospitalized for surgery SPN patients clinical data. SPN patients were divided into 95 cases of benign and malignant pathological results show benign and malignant lesions. Two groups of patients according to gender, age, smoking index, nodule size, clinical symptoms, the preoperative diagnosis and pathologic results, analysis of CT, PET / CT, fiber bronchoscopy, percutaneous needle biopsy, VATS diagnostic accuracy, and VATS and thoracotomy patients hospitalized days were compared, analyzed the advantages of VATS treatment of SPN. Results: The pathology diagnosis of 95 patients, 53 cases of malignant lesions, including 35 cases of adenocarcinoma, nine cases of adenosquamous carcinoma, squamous cell carcinoma, 7 cases of metastatic carcinoma of the two cases; benign lesions in 42 cases, including inflammatory pseudotumor cases of hamartoma, 13 cases of tuberculosis ball 15 cases, 4 cases of sclerosing hemangioma, five cases of lung cysts. Malignant lesions and benign lesions in significant differences in age and nodule size, no significant differences in gender, smoking index, and clinical features. CT of benign and malignant SPN to determine the sensitivity of 94.8%, a specificity of 54.2%. PET / CT examination of benign and malignant SPN to determine the sensitivity of 85.7% and a specificity of 66.7%. 14 patients with preoperative accept fiberoptic bronchoscopy, were unable to obtain a clear pathological diagnosis, all the patients were not receiving percutaneous needle biopsy. VATS SPN Malignant and Benign sensitivity and specificity of 100%. 35 patients underwent VATS, 60 patients undergoing open surgery, significantly reduced in the VATS patients hospitalized longer than patients with thoracic surgery. Whole group surgery was uneventful, and no serious complications and perioperative death and follow-up of 4 to 30 months, lost six cases, and the remaining patients were alive. Conclusion: The the malignant SPN incidence with the increase of age and nodule diameter increase, gender, smoking index, and clinical characteristics and the incidence of malignant SPN was no significant correlation. The diagnosis of SPN, CT, PET / CT specificity, bronchoscopy, the low sensitivity of percutaneous lung biopsy. VATS diagnosis and treatment of SPN, the technology is mature and viable, the results were satisfactory.
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