Dissertation > Excellent graduate degree dissertation topics show

The Study of Jiangzhibao Capsules

Author: ZhaoJun
Tutor: WenHao；GaoXiaoLi；WangJianHua
School: Xinjiang Medical University
Course: Pharmacy
Keywords: Jiangzhibao capsules preparation technology quality standard stability pharmacodynamics
CLC: TQ461
Type: Master's thesis
Year: 2007
Downloads: 57
Quote: 0
Read: Download Dissertation

Abstract


Objectives:The purpose of the research is to establish foundation for the development of a new preparation of the compound traditional Chinese medicine for hyperlipidemia.According to the study of new pharmaceutical preparation,this project before clinical trial includes four important sections:to study preparation technology,to establish the quality standard,to study the stability of the preparation,to study the main pharmacodynamics and the acute toxicology.Methods:①The preparation technology of Jiangzhibao Capsules was determined.The pre-process of Black Currant seed and the influence factor of stability of its powder were studied.The alcohol extracting procedure of Fructus Crataegi and the water extracting procedure of Glycyrrhiza and Fructus Crataegi which had been extracted by alcohol and the clarifying procedure of water extrac solution were separately screened by means of optimal experiment designs.The formulation procedure was screened by means of single-factor experiment design.②The quality standard of Jiangzhibao Capsules was established.Black Currant seed was identified by Microscopy.Fructus Crataegi and Glycyrrhiza was separately identifed by TLC.The content ofγ-1inolenic acid in Jiangzhibao Capsules was determined by GC.③Accelerating and long-term tests were conducted according to guidelines regarding the experiments of stability of medicine from the Chinese Pharmacopoeia(Edition 2005) to evaluate the stability of the product.④Xuezhikang Capsules used as reference preparation, the main pharmacodynamics was studied by observing the effect of the product on serum lipid and atherosclerotic plaque in experimental hyperlipidemia rats,mice and quails, respectively.The acute toxic reaction of mice was observed after they took Jiangzhibao Capsules orally.Results:①The pre-process of sterilization and comminution of Black Currant seed and packing material and storage condition of its powder were determined. The frequency and the time of extraction and the concentration and the volume of alcohol in the alcohol extracting procedure of Fructus Crataegi were determined.The frequency and the time of extraction and the volume of water in the water extracting procedure of Glycyrrhiza and Fructus Crataegi which had been extracted by alcohol were determined. The optium clarifiying procedure was determined.In the form of granule made by spray-drying process,the best formula of preparation and the best proportion of excipients were determined.②The quality standard of Jiangzhibao Capsules can practicably control the quality.③There was no obvious change with all indicators of the samples in the experiments monitored through the 3-month peried of accelerating and long-term tests.④The results of the statistical analysis showed that test drugs can not only lower the lever of TC,TG and LDL-C in serum and reduce the formation of atherosclerotic plaque in experimental hyperlipidemia animals,but also significantly better than reference preparation in quails except the lever of TG in serum(P＜0.01).With test drugs,the maximum tolerance dosage of mouse was as 2448 times as everyday dosage of adult according to body weight per kilo.Conclusions:①The preparation process is stable and suitable for new pharmaceutical preparation.②The quality standard of the preparation is feasible and contrlollable.③The initial stability of the preparation is sound and provides evidence for the feasibility of technology and packing material.④The results of the experiments showed that the preparation for hyperlipidemia is effective and safe.

Related Dissertations

  1. Analysis and Study of Abutment Stability in Concrete High Arch Dam by Three-Dimensional Nonlinear Finite Element Method,TV642.4
  2. The Study on Structural Calculation and Analysis Method of Lattice-type Crane with Variable Cross-section Boom,TH21
  3. Simulation and Analysis about Switched Reluctance Generator Power Supply System,TM31
  4. Stability Analysis of Systems with Time Delays,TP13
  5. Research on Input-To-State Stability of Discrete-Time Nonlinear Systems,TP13
  6. Thermal Stability of Complexes of Chitosan Quaternary Ammonium Salt and Metal Ion,O634
  7. Synthesis and Application of the chloro- methoxy fatty acid methyl esters,TQ414.8
  8. Breeding of High-Yield Pigment Production Monascus and Studies on Pigments’ Qualities,TS202.3
  9. On Ohba’s Conjecture of One Class of Complete Multipartite Graphs,O157.5
  10. Analysis of the Impact of Tailings Dam Stability under Seepage Role,TV649
  11. Characterization and Properties of capsaicin / CD system,TQ450.1
  12. Improvement of Preparation Technology for Chitin and Chitosan from By-product of Litopenaeus Vannamei,TS254.9
  13. Preparation and Properties of lead-free glass powder,TQ171.6
  14. Preparation and Evaluation on the Toxicological Safety and Stability of Deer Blood Wine,TS262.91
  15. Differeces in Physical and Chemical Properties and Organic Carbon Stability of Black Soil between Cropping Systems in Northeast China,S153
  16. Studies on Fingerprint Analysis and Total Flavone Extracts of Saussurea Involucrata ( Kar. Et Kir.) Sch.-Bip.,R284.1
  17. Study on Production Process and Quality Standards of the QingReTouTong Soft Capsule,TQ461
  18. Study on the Preparation Technology and Quality Standard of Danggui Dropping Pills,TQ461
  19. Research on Genetic Stability of Recombinant Pichia Pastoris and Purification Strategy of Poifn-a,S828
  20. Study on the Preparation Technology and Quality Standard of Tongmai Drop Pills,TQ461
  21. The Reform and Study Ofsite-directed Mutagenesis of Acid Xylanase XynⅢ from Aspergillus Niger,TQ925

CLC: > Industrial Technology > Chemical Industry > Pharmaceutical chemical industry > The Chinese herbal medicine preparations of the production
© 2012 www.DissertationTopic.Net  Mobile