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Research on the Preparation and Properties of Silk Fibroin/Calcium Phosphate Composite

Author: WangBiao
Tutor: XieRuiJuan
School: Suzhou University
Course: Textile Engineering
Keywords: silk fibroin tetracalcium phosphate calcium phosphate cement composite
CLC: R318.08
Type: Master's thesis
Year: 2011
Downloads: 26
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Abstract


In this paper, silk fibroin/calcium phosphate composite was prepared and its structure and properties were studied, based on the preparation of calcium phosphate cement (CPC).As one of the main components of CPC, tetracalcium phosphate (TTCP) was prepared by wet method from the presoma, which was calcined in furnace and cooled in different ways. The results showed that the cooling way had a significant effect on the purity of TTCP. The temperature was the key factor to the purity of TTCP, when the sample was moved out from the furnace. Airing nitrogen or not had no obvious effect on the purity of TTCP during the temperature declined from 1500℃to 1300℃. The sample was moved out at 1300℃and quenched in air, high purity TTCP could be gained.In this study, we chose CPC with silk fibroin (SF) added as solid phase and phosphate buffered solution as liquid phase to prepare silk fibroin/calcium phosphate composite, which had injectability, appropriate setting time, good mechanical properties and biocompatibility, and could self-setting, so it could be used for bone repair and substitution. The effect of different mass fraction of SF and liquid to powder (L/P) ratio on the surface morphology, structure and properties of silk fibroin/calcium phosphate composite were researched respectively. The results indicated that different mass fraction of SF and L/P ratio all had no significant effect on the surface morphology and structure of composite, the crystal of hydroxyapatite (HA) existed in all composites. The effect of different mass fraction of SF on the properties of composite: different mass fraction of SF had less effect on the porosity and density, the porosity was 38-40.5%. Their setting times were all between 9 to 15min. Compared to pure CPC, the compressive strength and work-of-compressive of composites all improved. With 1% SF added, the compressive strength increased obviously. The effect of different L/P ratio on the properties of composite with 2% SF: when L/P ratio was 0.32-0.34ml/g, L/P ratio had no significant effect on the porosity and density, L/P ratio was 0.34-0.39ml/g, L/P ratio had an obvious effect on the porosity and density. With the increase of L/P ratio, the porosity increased and the density decreased. With the increase of L/P ratio, L/P ratio was 0.32-0.34ml/g, the compressive strength of composite increased, while L/P ratio was 0.34-0.39ml/g, the compressive strength of composite decreased. When L/P ratio was 0.34ml/g, the compressive strength was greatest and work-of-compressive was greater. About injectability, it increased with the increase of L/P ratio, the injectability increased slowly when L/P ratio was 0.32-0.36ml/g, however, it increased remarkably while L/P ratio was 0.36-0.39ml/g. The cytotoxicity evaluation in vitro showed that the composite we prepared in this paper was nontoxic or light toxic and accordance with the need of biomaterial cytotoxicity.

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CLC: > Medicine, health > Basic Medical > Medical science in general > Biomedical Engineering > General issues > Biomaterial
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