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The Effects and Mechanisms of Vitamin-K1 on Fracture Healing in Aged Rats

Author: XueXiaoFeng
Tutor: YinZuoSheng
School: Shanxi Medical
Course: Orthopedics
Keywords: osteoporosis facture healing animal experiment Vitamin-K1 IL-6 BGP ALP
CLC: R683
Type: Master's thesis
Year: 2008
Downloads: 97
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Abstract


Objective:To investigate the effects of Vitamin- K1 on osteoporotic fracture healing in aged rats.Methods:The status of osteoporosis in 20-month-old male rats was confirmed by total body bone mineral density measurement.Fracture healing model was established by osteotomy with a wire saw and fixation with a Kirschner pin on left femur.64 model rats were randomized into two groups:32 for control group,and 32 for Vitamin-K1 group.Vitamin-K1 group was given intraperitoneal injection of Vitamin-K1 at dose of 15mg/kg/3d,while control group was given an equivalent volume of saline.The rats were scarified in 2,4,8 and 12 weeks after operation,the callus formation was monitored by histological and interleukin-6（IL-6）,bone gla protein （BGP）,alkaline phosphatase（ALP）,calcium（Ca） in the blood-serum,the bone mineral density measurement of the callus and the right femur was taken,normal radiographs were taken at 12 weeks.The measurement data was expressed by mean±standard deviation（（?）±s）.The experimental groups and the control groups were compared with the number of matching design of quantitative information t-test,and P＜0.05 was for the difference statistically significantResults:1.Vitamin-K1 produced a significant increase in serum BGP,Ca×P,ALP and. decrease in serum IL-6.2.Vitamin-K1 group had higher bone mineral density（P＜0.05）.3.The histomorphological analysis revealed that the process of cartilage forming and transforming were advanced in Vitamin-K1 group.4.Normal radiographs showed Vitamin-K1 group had more callus formation.Conclusion:1.Vitamin-K1 can.advance the osteoporotic fracture healing in aged rats.by increasing BGP,Ca,ALP in serum and.decreasing IL-6 in serum.2.During the healing process,vitaminK1 can accelerate endochondral bone formation and make increase the bone mineral density of bone callus and systemic bone.

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CLC: > Medicine, health > Surgery > Orthopaedic Surgery ( movement system diseases,orthopedic surgery ) > Fracture,bone damage
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