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T_2 ~ * Figure (T_2 ~ * map) monitoring articular cartilage damage in clinical and experimental research

Author: HouXiaoXia
Tutor: LiuSiRun
School: Jinan University
Course: Imaging and Nuclear Medicine
Keywords: MRI Articular cartilage Degeneration T2 * Figure T2 * values
CLC: R445.2
Type: Master's thesis
Year: 2008
Downloads: 83
Quote: 0
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Abstract


Objective To investigate the MRI T 2 * Figure right patellar cartilage degeneration clinical diagnosis MATERIALS AND METHODS four pigs 8 back knee , the right knee joint cavity injection of papain -induced arthritis, left knee as a control , MRI scans measuring T 2 * value differences within each group were compared with pathological findings . 105 patients with osteoarthritis , 19 with acute trauma , 50 healthy volunteers underwent MRI scans take 27 patellar cartilage regions of interest , measuring T 2 * value , comparing differences within each group . The results were successfully induced porcine knee arthritis, knee and within each group left knee T 2 * value of the difference was statistically significant, pathology showed cartilage cells, mucopolysaccharide gradually decreased, indicating that T 2 * diagram can be used to articular cartilage degeneration clinical study , which concluded as follows: 1 , normal patellar cartilage , the external inter- T 2 * values ??are significantly different . Each part from the inside to the table shallow T 2 * value was increased, and there is a significant difference ( each group P <0.001). 2 , osteoarthritis group patellar cartilage , the external inter- T 2 * values ??are significantly different . Outside T 2 * value than the inside height , from the inside to the various parts of the table shallow T 2 * value was increased, and there was significant difference ( each group P <0.001). 3 , the normal group T 2 * is lower than the same age osteoarthritis group, the difference was statistically significant. 4 , the normal group T 2 * is lower than the same age sports injury patellar cartilage , the difference was statistically significant. Conclusion T 2 * Figure energy reactions caused by degeneration of cartilage structure , composition and content of water molecules changes so that radiological diagnosis of early cartilage damage fine to the molecular level .

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