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Organic tin compound as a Lewis acid catalyst in the field of organic synthesis has many advantages . To explore the different structures of organotin compounds on the catalytic performance of esterification , this paper Bu2SnCl2, Bu3SnCl, Ph3SnCl, SnCl4 as the starting material was synthesized organotin compounds Bu2SnO, Bu2Sn (OCOPh) 2, (Bu3Sn) 2O, Bu3SnOCOPh, Ph3SnOH, Ph3SnOCOPh, (Me3SiCH2) 2SnCl2, (Me3SiCH2) 3SnCl. By Benzyl Acetate esters and propionic acid butyl ester , the catalytic activity of organotin studied. Single factor and orthogonal experimental method , focusing on the amount of catalyst , reaction temperature, reaction time, the molar ratio of acid to alcohol and water carrier and other factors on butyl benzyl acetate and propionate esterification rate. Experimental results show that the second hydrocarbon group and the trialkyltin esterification organotin compounds on the catalytic activity have a certain , wherein Ph3SnCl, (Me3SiCH2) 3SnCl better catalytic effect . Of n ( acetic acid ): n ( benzyl alcohol ) = 2.5:1, Ph3SnCl an amount of benzyl alcohol and 1.5% of the total mass of acetic acid with toluene, the amount of agent lOmL ( toluene molar ratio of 0.95 ) , the reaction after 150min conditions , benzyl acetate esterification rate reached 97.8% . In (n ( butanol ): n ( acid ) = 1.7:1, Ph3SnCl propionic acid and alcohol consumption is 2.0% of the total mass , the amount of cyclohexane 10mL ( with propionic acid molar ratio of 0.46 ) , under the reaction conditions after 120min , butyl propionate esterification rate was 97.3 % of n ( acetic acid ): n ( benzyl alcohol ) = 3.5:1, (Me3SiCH2) 3SnCl amount of benzyl alcohol and acetic acid is the total mass 2.0% , with the agent in an amount of toluene 10mL ( toluene molar ratio of 0.95) under the reaction conditions after 210min , benzyl acetate esterification rate of 91.5% to reach the study results showed that the catalytic esterification of organic tin compounds , high catalytic activity , mild reaction conditions , the catalyst was less , corrosion reaction apparatus , etc. in view of this , an organic tin compound in the production of esters of perfume has good application prospect.
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