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Study on Lab-scale Process Development and Manufacture of Atipamezole HCI

Author: ChangZongCe
Tutor: LiangYongMin
School: Lanzhou University
Course: Applied Chemistry
Keywords: Hydrochloric acid atipamezole Synthesis Pilot Quality standards
CLC: TQ463.53
Type: Master's thesis
Year: 2010
Downloads: 64
Quote: 1
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Abstract


Articaine hydrochloride US oxazole , chemical name : 4 - ( 2 - ethyl-2 - indanyl ) imidazole hydrochloride . Hydrochloric A influenza behalf of US azole competitive inhibition α2 adrenergic receptor , is an effective α2 adrenergic receptor blocking drugs , selective and competitive , effective inhibition of α2 adrenergic receptor . Its pharmacological effect is to reduce the sedation , lower blood pressure , increased heart and breathing rates , as well as reduce the analgesic effect of α2 -adrenergic receptor blocking drugs , mainly used in the animal body after surgery anesthesia recovery . Hydrochloride atipamezole as hypoglycemic and antihypertensive drug research in the clinical evaluation stage . Meanwhile, the drug in the treatment of asthma , obesity , migraine headaches , and memory loss caused by age has a certain effect . Articaine hydrochloride U.S. azole domestic and foreign production less foreign demand . In our inspection on the basis of relevant literature , compared to the existing synthesis process to determine a route for industrial production , and a small pilot process development and optimization , has been the target product by elemental analysis, infrared spectroscopy , ultraviolet spectroscopy , nuclear magnetic resonance , mass spectrometry , and other testing methods to determine its structure . Based on the completion of the a small trial process research , we were development of hydrochloric A scale-up process in behalf of the United States azole , and quality control on each step intermediates by high-performance liquid chromatography , so as to ensure the production of qualified hydrochloride A behalf of the United States azole products . Hope that through these efforts provide a strong basis for future industrial production of .

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CLC: > Industrial Technology > Chemical Industry > Pharmaceutical chemical industry > Production of organic compounds in drug > Heterocyclic compounds drugs > Five section heterocyclic
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