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The Study on the Preparation and Quality Standard of Anti-Inflammatory Dental Ulcer Filmogen
Author: WangFan
Tutor: HeXin
School: Heilongjiang University of Traditional Chinese Medicine
Course: Pharmacy
Keywords: Mouth ulcers Composite film former Preparation Process Quality standards Qingdai Hydrocortisone
CLC: TQ463
Type: Master's thesis
Year: 2010
Downloads: 58
Quote: 0
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Abstract
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Heilongjiang Provincial Hospital clinical applications for many years \>) is a very effective drug to treat mouth ulcers , but are glycerin paste ulcer with partial can not be fixed , the efficacy is limited . The \The blank membrane isolation layer , you can cover up the bad taste , so contained pellicles unidirectional release , the drug concentration in the affected area in a timely manner efficacy play to extend the time of drug action ; Add borneol , Qingdai , pearl powder and on the basis of the original prescription to increase detoxification, blood stasis , the myogenic analgesic efficacy . Mouth ulcers the preparation process of the composite film former is confrontation , and to develop the quality standards of the anti-oral ulcer film former , examines the impact factor of the anti-oral ulcer film former and preliminary stability . In this study, the use of UV spectrophotometry , by examining the dissolution testing means to determine PVA17-88 as set out in the emulsion side of the film-forming material , PVA17-99 as a the blank film film-forming material ; orthogonal experimental design method to determine the preparation process set out in the film with the best ; the cumulative penetration visits to determine the carrier pellicles Azone content . Physicochemical identification or TLC identification of drugs against oral ulcers film former qualitative research . And high performance liquid chromatography the which the major drug Qingdai and the hydrogenated cortisone determination of the method of research, while establishing the quality standards of the anti-oral ulcer film former . In order to ensure that the clinical application of therapeutic effect against the influencing factors of oral ulcers film former and preliminary stability inspect , experimental results show that the preparation in high temperature conditions , 60 ℃ , indirubin content decreased , 40 ℃ when indirubin contents stability; hydrocortisone showed no significant change in the conditions of humidity 75% ± 5% ; in the light conditions , the formulation of indirubin content was significantly reduced , so that the formulations may conveniently stored at below 40 ℃ dark conditions .
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