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Numerical Method Based Research on Electrical Activities of Cerebral Neuron

Author: NiuGuoYi
Tutor: WangXiaoYuan
School: Tianjin University
Course: Motor and electrical
Keywords: Electroencephalogram Dipole Electromagnetic Field Potential Neuron
CLC: Q42
Type: Master's thesis
Year: 2007
Downloads: 112
Quote: 1
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Abstract


Brain is the sources of consciousness. Many scientific researchers are always attracted by the study of cerebrum. The configuration of brain is complex; cerebral cell connects with each other not only by macroscopically electricity and magnetism, but also by the change of molecular and elementary particle. Simulation is one of available and no-hurt ways to study brain which controls thought, consciousness, study, memory and so on. An aggregation of morphologically similar cells and associated intercellular matter acting together performs electrical activity. It is a way to simulate the production of electric potential between parts of brain in common use. Firstly, it needs simulate the processing of cause and spread of electric potential between parts of brain; then it needs to work out electric potential on the surface of head from the model which was used for further imitating its characteristics based on the electric activity originated by the excited nerve cell and the magnitude, orientation of nerve cell. Once we succeed in gaining the model of brain, we can imitate the process of much abnormal disease of the nervous system by setting the parameters of model. We can study the mechanism thoroughly, through which abnormity of brain comes into being on the basis of electric potential on the surface of scalp and model we previously design to study brain.This article tells of the electrical characteristic of biologic tissue from the angles of resting potential and action potential relating to cell. It also introduces the process of producing action potential, the mechanism and measurement of brain wave and also. It describes and calculates the electric field caused by brain on the principle of electromagnetism too. It gives the process of calculating brain’s electric field using finite-element analysis subsequently. Electric dipole with electric dipole moment can simulate the electric activity of neuron. Aimed at four spheres with one centre of a circle representing head, this article simulates the problem of brain’s electric field using the model of one current dipole with difference electric dipole moment and moment changes along with time based on finite-element analysis. The model of two current dipoles is also used in the article to compare with those results of one. Afterward, it simulates the magnetic field characterized by the existence of electric field of brain on the heap of single electric dipole. The article compares and analyzes the similarities and differences of those electrocardiograms gained through stimulation. Through the comparison of results, we found using the model of electric dipole can simulate electric field and magnetic produced by neuron. The results of simulation are accordance with the truth. The conclusion of simulation shows that potential of the area which closes up the dipole is high, while the potential of scalp is lower with the increase of the distance between the point of observation and the dipole. The electric activity of neuron with different intensity and orientation may come into being electromagnetic which is different from each other. At last, the article describes ways and means available to deduce the coordinate and intensity of neuron by the process of reverse-calculation according to the potential of scalp. We can obtain the information of neuron’s activity through the analysis on EEG to study of diseases of brain and its causes, processes, development, and consequences ,which provides the evidence and reference of brain’illness to help diagnoses and prevention.

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CLC: > Biological Sciences > Physiology > Neurophysiology
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