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Dexamethasone is a typical adrenal corticosteroids , anti-inflammatory, anti-toxin , anti-allergic , anti-shock and pharmacological effects , clinical aspects , has a very important significance . Currently, its intermediate 11β- hydroxy - progesterone -1,4,16 - triene -3, 20 - dione production exists process behind the crystal exquisite low yield, low purity , small particle size , and other issues , this article 11β- hydroxy progesterone -1,4,16 - triene-3 ,20 - the diketone Solventing - cooling crystallization process more systematic study . Training 11β- hydroxy progesterone -1,4,16 - triene -3, 20 - dione single crystals by X - ray single crystal diffraction to determine the crystal structure using natural cooling method . Application Cerius2 molecular design software analysis the vacuum in BFDH model and AE model crystal form . And the effects of temperature on the crystal habit . Dynamic Determination of 11β- hydroxy - progesterone ratio under the different temperature and solvent -1,4,16 - triene -3, 20 - dione solubility . And solubility λh equation by regression . 11β- hydroxy progesterone -1,4,16 - triene -3, 20 - dione in mixed solvents under different temperature metastable zone using the laser method , to provide a basis for the determination and improvement of the process . Intermittent dynamic determination of 11β- hydroxy- progesterone -1,4,16 - triene -3, 20 - dione Solventing - Cooling crystallization dynamics . Use of moment transformation method of experimental data processing , the the unrelated growth granularity no poly -breaking dynamics model , and the effects of temperature , stirring speed of the secondary nucleation rate and growth rate . Purity and yield of the target system to study the crystallization conditions ( crystallization temperature , seed , eluent flow rate of acceleration , stirring rate , raising grain time , the crystallization of the final temperature ) dissolved Analysis - cooling crystallization process , initially identified the best experience operating process . The process to improve the yield and purity of the product , the experimental product size , not coalescing perfect crystal form . The results of the study provide the basis for 11β- hydroxy- progesterone -1,4,16 - triene -3, 20 - dione crystallization process of further research and industrial production . The work and the results of the above study are not reported.
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