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VB 12 fermented liquid filtration is an important operational aspects of drug preparation process , a direct impact on product yield , quality and production efficiency . Direct filtration methods can not satisfy the industrial production, in the case of without alteration of the original filtering equipment ( plate and frame filter ) experiment adding flocculant pretreatment , and then using diatomite pressurized filtration experiments , to study the main factors affecting the filtration rate , improve cake structure , to achieve the effect of solid-liquid separation . Thesis selected by flocculant orthogonal experiment, flocculant own nature , the added amount of flocculant , water pH , stirring speed and stirring time as the influence factors , VB 12 fermentation broth optimum flocculating conditions , i.e. flocculant for the PAC and the added amount of 7 % , a pH value of 7 , the stirring speed 1.26M / s , the stirring time is 45s . Then by adding a filter aid to the cake structure to be modified. The experiments show that the use of coarse particles of celite , added in an amount in the case of 3% , the filtration rate can be increased 1.5 2 .5 times . Controllable and simple operation , easy to industrial applications . Papers by electron microscope observation of the morphological characteristics of the flocs , studies have shown that : flocs form a greater impact on the cake structure and filtration process . PAC granular floc than organic flocculants filamentous flocs more conducive to improve the filter cake structure , improve the filtration rate .
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