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Probing the Manufacture Process of Methyl Cobalamin

Author: YangChaoZuo
Tutor: MaPeiSheng；ZhouXiaoBing
School: Tianjin University
Course: Pharmaceutical Engineering
Keywords: Methyl VB12 Cyanocobalamin VB12 Resin Adsorption
CLC: TQ466.2
Type: Master's thesis
Year: 2007
Downloads: 45
Quote: 0
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Abstract


The methyl VB12 role in vivo methylation conversion and folate metabolism , maintain normal morphology and function of blood cells , as well as the functional integrity of the nerve fibers . Clinical diabetes neurological disorders , polyneuritis peripheral nerve disease had a significant effect . In this paper, the main factors affecting the methylation reaction , derive an empirical equation of the methylation reaction rate . And three main factors orthogonal experiment, preferably methylation reaction conditions were identified on three levels . Then, the main factors affecting the solid adsorbent solute adsorption from solution . Macroporous adsorbent on the adsorption behavior of methyl VB12 and from the two aspects of the adsorbent and adsorbate , to discuss and screened resin suitable for the adsorption of methyl VB12 . On this basis , this adsorption process , the optimization of the adsorption and desorption conditions to identify the optimum adsorption pH, the adsorption rate and the desorption pH of the ratio of desorbent and other operating parameters . As can be seen by the pilot production and large-scale production , the process is a more reasonable preparation process .

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CLC: > Industrial Technology > Chemical Industry > Pharmaceutical chemical industry > Vitamin manufacturing > Vitamin B
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