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The study of the bone ribs capsule preparation process quality standards . Study on the preparation by orthogonal experiment preferable the best alcohol extract and decoction extraction process by molding experiment , and a smooth transition to the pilot , so as to provide reasonable technical parameters for large-scale production , stability experiments show , the process is feasible . Quality standards study examines the identification, examination and Determination of the project . Identification of major research Smell of bone tendons capsule Panax, dragon's blood , Nux vomica , Gentiana , fumarate , etc. through the a strong specificity thin layer chromatography . Content was measured by a convenient high-performance liquid chromatography each other in the main drug Strychnos contained taxis strychnine and brucine , Gentiana contained gentiopicroside content determination . This product each containing strychnine to disabilities Ning (C21H22N2O2) count , 0.30mg ~ 0.50mg; strychnine (C23H26N2O4) shall be not less than 0.20mg ; the containing Gentiana gentiopicroside ( C16H20O9) Interest shall not be less than 3.0mg . The quality standards to eliminate the interference of the complex components of traditional Chinese medicine preparation , prescription ginsenosides Rg1 , Rb1, notoginsenoside R1, the strychnine , gentiopicroside , tetrahydropalmatine Xuejie TLC identification ; Determination of strychnine , brucine , gentiopicroside glycosides , the method is simple , good reproducibility and precision . The research , to ensure the the bone ribs capsule clinical drug rationality , safety and efficacy .
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