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Synthesis, Characterization and Properties of Anti-protein Materials Containing PLLA

Author: LiLiLi
Tutor: ZhaoYunHui
School: Tianjin University
Course: Materials Science
Keywords: PLLA PLLA-POEM-BMA MPC PLLA-MPC-BMA Hydrophilic Protein adsorption
CLC: R318.08
Type: Master's thesis
Year: 2007
Downloads: 113
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Abstract


Has good biocompatibility and blood compatibility performance the biodegradable coating is implanted in the body to become a research hotspot . Bearing phosphorylcholine groups material has excellent biocompatibility and hemocompatibility traditional synthetic methods very harsh conditions , \problem, it is rarely used; the PEG group - containing material having a good hydrophilicity and biocompatibility for the preparation of the coating material , often in combination with other materials ; polylactic acid is biocompatible biodegradable polyester, based on this , the paper were synthesized based PLLA containing phosphatidylcholine and PEG groups two biodegradable coating , and the performance of the two were compared . The experiment begins with the synthesis of the polylactic acid macromer (PLLA) , were synthesized containing the PEG group of PLLA - POEM -BMA ; through the \acyloxyethyl phosphatidyl choline (MPC), and MPC PLLA polymerization prepared PLLA-MPC-BMA. By 1H-NMR and FT-IR to characterize the structure of the synthetic substances , and studied the influence of the monomer feed the polymer composition ; investigated through the determination of the contact angle of the polymer hydrophilic ; research time on the polymer the influence of the amount of adsorbed protein , and the use of SEM observation after different adsorption time , the surface morphology of the PLLA-POEM-BMA ; to study the thermal properties of the polymer by DSC ; last the PLLA-POEM-BMA and PLLA-MPC-BMA the synthesis conditions , hydrophilic, protein adsorption and other aspects of the comparison. The results show that : the end with the double bond of the macromonomer of PLLA , and by the feed ratio to control molecular weight ; 1H- NMR and FT-IR analysis showed that the synthesized MPC HEMA and stannous octoate as catalyst , the PLLA-POEM-BMA and PLLA-MPC-BMA precisely the design of substances , and the proportion of the respective structural units with the monomer feed ratio in the copolymer is substantially the same as described can be controlled by controlling the feed to the composition of the copolymer ; through two copolymer contact angle was measured and found to the PLLA-MPC-BMA contact angle less than PLLA-POEM-BMA, i.e., hydrophilicity of the former over the latter ; showed different time (8h and 24h) Determination of the amount of adsorbed protein , PLLA-MPC-BMA far less than the amount of adsorbed protein the PLLA-POEM-BMA, the former have better resistance to protein adsorption .

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CLC: > Medicine, health > Basic Medical > Medical science in general > Biomedical Engineering > General issues > Biomaterial
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