Dissertation > Excellent graduate degree dissertation topics show

The Synthesis of the Precursor of 3’-deoxy-3’-[18F]fluorothymidine ([18F]FLT)

Author: WangRong
Tutor: JiangShenDe
School: Tianjin University
Course: Medicinal Chemistry
Keywords: Positron Emission Tomography(PET) PET Radiopharmaceuticals [18F]Labelled 3’-deoxy-3’-[18F]fluorothymidine（[18F]FLT） precursor
CLC: R914
Type: Master's thesis
Year: 2007
Downloads: 41
Quote: 0
Read: Download Dissertation

Abstract


Positron emission tomography (PET) is a powerful medical imaging method for measuring the distribution of the positron emitter in the human body by co-incidence of the annihilation photons resulting from positron decay. One of the positron emitting isotopes is fluorine-18 that is often used as a substitute for hydrogen in organic molecules with a half-life of 110 minutes, which allows complex synthesis and detailed imaging studies.3’-deoxy-3’-[18F]fluorothymidine([18F]FLT) appears to be the most promising radiopharmaceutical. It is under clinical evaluation as a metabolic probe for imaging cell proliferation in vivo using positron emission tomography(PET).In order to improve the [18F]FLT production, according to the reported synthetic route, BATH, DMTThy, 3’-O-mesyl-thymidine derivative and its pyrimidine ring N-BOC-protected analogue as precursors for [18F]FLT were synthesized. The reaction conditions and results were also described in this study.In addition, the fluorination of the precursors was also discussed.

Related Dissertations

  1. Study on the Screening of Doramectin-producing Strains by Nitrogen Ion Implantation and Optimization of Fermentation,S859.79
  2. Study on Transformation and Biosynthesis of Saikosaponin in Adventitious Root Culture of Bupleurum Chinense DC.,R284
  3. High glucose in human umbilical vein endothelial cells expression of renin precursor,R543.5
  4. To Explore the Value of Plasma NT-proBNP and Hypersensitive C-reactive Protein in Evaluating the Prognosis of the Patients with Acute Coronary Syndrome,R541.4
  5. Design and Implementation of Data Transmission on Micro-PET,TN919.3
  6. Boron nitride fiber reinforced ceramic matrix composites through the waves and Properties,TB332
  7. Retrospective Study about the Prognostic Value of N-terminal Pro-B-type Natriuretic Peptide and APACHE Ⅱ Score in Elderly Patients of SICU,R459.7
  8. Preparation and Application Studies on the Hydroxycarboxylic Acid Titanic Complexes,O627.4
  9. Research on the Microvascular Self-healing Material for Thermal-protection Application,V250.2
  10. Increasing Survival Rate of 3T3-L1 Preadipocyte by Hyaluronic Acid Scaffold Combined with VEGF,R329
  11. Precursor polymer prepared SrBi_2Ta_2O_9 ferroelectric ceramics and thin films and its properties,TQ174.1
  12. The Effect of GAS on Aβ Secretion in APP Overexpressed Cells,R285
  13. Hunan Hengyang Han population NARC-1/PCSK9 gene polymorphism and serum levels with Coronary Heart Disease,R541.4
  14. Effects of Exogenous Hydrogen Sulfide on Amyloid Precursor Protein/Beta-Amyloid Processing and the Expression of Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 in Pheochromocytoma Cells,R749.16
  15. Synthesis and Characterization of Polycarbosilane Containing Allyl,O634.41
  16. The Design and Implementation for Random Access of LTE Uplink,TN929.5
  17. X-ray Scattering Detection and Identification Algorithm of Precursor Chemicals,TP274.51
  18. Screening Gene Mutation of Familial Alzheimer’s Disease and Construction of APP Expression Vectors,R749.16
  19. New Evidences for Phase-Equilibrium-Dominated Vapor-Liquid-Solid Growth Mechanism, Morphology-Controlled Synthesis of Chromium Silicide Nanostructures and Their Field Emission Properties,TB383.1
  20. Preparation and Characterization of Multiferroic Materials,TB34
  21. Chemical precursor prepared TiB_2-SiC nanocomposites,TB383.1

CLC: > Medicine, health > Pharmacy > Drug basic science > Medicinal Chemistry
© 2012 www.DissertationTopic.Net  Mobile