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Objective: fetal cholinergic system plays an important regulatory role in the cardiovascular and endocrine function . This topic focuses on cardiovascular responses and their endocrine mechanism of fetal cholinergic system is activated . Method : the application of non-stress conditions to detect intrauterine fetal sheep experimental model of multiple functions in the body dynamic continuous recording intravenous the carbachol fetal sheep cardiovascular function indicators such as systolic blood pressure , diastolic blood pressure , mean arterial pressure , heart rate , systolic and diastolic period changes. The same time , drug delivery ( recorded at baseline ) and after intravenous injection of carbachol to collect blood samples of fetal sheep , with measured by radioimmunoassay vasopressin , angiotensin I and angiotensin II , nitric oxide ( NO ) and other hormone levels and fetal sheep plasma pH was measured with a blood gas analyzer PO 2 < / sub > , the PCO 2 < / sub > , Hb , Hct , and glucose , lactic acid , Na < / sup > and K of < / sup > concentration changes . Results : fetal sheep intravenous injection of carbachol , blood pressure first, a transient decrease and then increase , temporary decrease in blood pressure associated with a decrease in heart rate . Injection of carbachol fetal sheep circulating angiotensin I and II increased secretion of vasopressin did not affect plasma NO INS showed no significant change . Fetal sheep blood gas analysis including the blood Na , the K < / sup > , osmotic pressure , Hb , Hct did not change significantly . Conclusion: The fetal sheep intravenous cholinergic agonist carbachol can cause fetal sheep cardiovascular function ( such as blood pressure ) changes , this reaction may be related to fetal sheep peripheral renin - angiotensin system function changes .
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