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Tanshinone Ⅱ A sulfonate Chinese scholars study the chemical composition of Salvia Tanshinone Ⅱ A sulfonated obtained water-soluble sulfonates . Pharmacological studies have shown that the effective increase in coronary blood flow , improves cardiac metabolism , have a significant effect on angina pectoris and chest tightness , injection has been widely used in clinical . Tanshinone Ⅱ A sulfonate research focused on the pharmacological activity , the sulfonation process byproducts and impurities of or blank Summary of tanshinone Ⅱ A sulfonate progress , the establishment of tanshinone Ⅱ A sulfonic sodium reference substance preparation , preparation of a certain amount of reference substance , and its structure was confirmed by spectroscopic methods ; based on low pressure reverse phase chromatography and gel permeation chromatography of trace impurities in bulk drugs separation , seven chemical composition , by the spectral analysis and compared with the control to confirm which tanshinone IIA , 3 - hydroxy tanshinone IIA sulfonate, sodium tanshinone Ⅰ , Δ1- tanshinone IIA sulfonate three additional components through now complete spectrum analysis , initially identified as 3 - hydroxy tanshinone IIA sulfonate, sodium tanshinone Ⅰ , Δ1- tanshinone IIA sulfonate and diethyl sulfate or other substances to form some form of the substance , further confirmation of the work is still in progress . The same time , the paper established a high - performance liquid chromatography method for determination of bulk drugs and formulations tanshinone Ⅱ A sulfonate content , and can be used for quality control of bulk drugs and formulations .
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