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The Study of the Active Compounds of Zanthoxylum Nitidum and Application of Oral Care Products

Author: YangWeiHao
Tutor: WangJianXin；ZuoQingYun
School: Jiangnan University
Course: Chemical Engineering
Keywords: Nitidum New rod pepper amide Nitidine chloride Analgesic Anti-inflammatory Hemostatic
CLC: R78
Type: Master's thesis
Year: 2008
Downloads: 205
Quote: 1
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Abstract

On both sides of the needle analgesic, anti-inflammatory and hemostatic active ingredient a thorough study, found that the main component of the both sides of the needle - new rod pepper acid has analgesic, anti-inflammatory and hemostatic biological activity; chloride The nitidine have some anti-inflammatory biological activity. This will provide a scientific basis for the development and application of both sides of the pin. The main contents of this paper are:. Determine the various parts of the nitidum extract a significant part of the analgesic, anti-inflammatory and hemostatic biological activity nitidum ethanol extract (S-0) is divided into three parts: that both sides needle ethanol extracts of ether extracted portion (S-1), the the total alkaloids portion (S-2) and extracted after the remaining portion (S-3). Determined by pharmacological experiments, nitidine ether extracts part of the extract (S-1) has a significant analgesic, anti-inflammatory and hemostatic biological activity. Acute toxicity test results show that the ether extracts part of the LD ₅₀ for 68.85 ± 10.31mg/kg weight. 2 has a significant part of the chemical composition of the biological activity of the analgesic, anti-inflammatory and hemostatic separation by column chromatography and isolated from both sides of needle portion of the extract extracted with ether (S-1) of the five compounds, by ^{1 HNMR, ^{13 CNMR ^{1 the H-^{1 HCosy, HMQC, MS, IR and UV identification, they are: β-Hong resin alcohols (β-amyrin); L-sesamin (L-sesamin); the L-Asarum fat hormone (L-asarinin); There is a major, have significant analgesic, anti-inflammatory and hemostatic biological activity the new rod pepper acid (noeherculin), the yield was 0.28%. In addition, the total base number (S-2) from both sides of the needle extracts isolated the nitidine chloride (nitidinechloride) yield of 0.0088%. Found new rod nitidum pepper amide significant analgesic, anti-inflammatory and hemostatic biological activity nitidine chloride has anti-inflammatory activity the the new rod pepper amide and chlorinated nitidine by pharmacological experiments the animal analgesic, anti-inflammatory and hemostatic experimental results show that the new rod pepper acid has significant analgesic, anti-inflammatory and hemostatic biological activity, LD ₅₀ 16.96 ± 2.45mg/kg body weight ; the chloride nitidine have some anti-inflammatory activity, which may provide a reliable scientific reference for the development and application of both sides of the pin. 4. The Guangxi ten different origin of Chinese medicine nitidum determined by analysis of the new rod pepper amide and chloride nitidine ingredients to nitidum significant analgesic, anti-inflammatory and hemostatic biological activity of the new rod pepper amide with certain anti-inflammatory activity nitidine chloride as reference, of Guangxi ten different origin nitidum carried Determination of the active ingredients found the Jinxiu nitidum raw content of the active ingredient in a maximum of 0.468%; Guangxi The Bose nitidum chloride content nitidine up to 0.467%. This will likely provide scientific reference for the nitidum the development and application of the best raw materials, selection and the best choice of planting base. The selection of the optimal extraction conditions of 5 nitidum in new rod pepper amide by orthogonal experimental design, using reflux extraction method with analgesic, anti-inflammatory and hemostatic activity of the new rod pepper amide extracted influencing factors on both sides of the needle, solvent, extraction time and temperature were investigated and found different extraction conditions, the active ingredient the nitidum extract new rod pepper amide content varied significantly. In 75% ethanol, 75 ℃ temperature, the time of 3 hours under the conditions of both sides of the needle to extract liquid coryneform pepper amide highest content reached 0.76%; in water as solvent, 50 ℃ temperature, time 1 hour under the conditions, amide content of the new rod pepper the nitidum extract a minimum of only 0.00070%. The new rod pepper amide and nitidine chloride determination in the the 6. Nitidum Chinese toothpaste extract nitidum (S-0) by a certain percentage is added to toothpaste made the nitidum Chinese toothpaste to determine New rod pepper amide and chloride nitidine for reference standards, can be detected by high performance liquid chromatography (HPLC) analysis of the content of the the new rod pepper amide and chloride nitidine nitidum Chinese toothpaste; established nitidum Chinese toothpaste the the new rod pepper amide and nitidine chloride detection analysis method; stable determination of the new rod pepper nitidum Chinese toothpaste amide and chloride nitidine, content. Will nitidum the Chinese toothpaste applications and nitidum of traditional Chinese medicine toothpaste establishment of quality standards to provide a scientific basis has important theoretical value and application prospect.}}}}

The Study of the Active Compounds of Zanthoxylum Nitidum and Application of Oral Care Products

Abstract

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