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The warm liver Zhichan Clinical and Experimental Research Jiaoxiang the treatment of Parkinson 's disease

Author: YaoXin
Tutor: GaiGuoZhong
School: Changchun University of Traditional Chinese Medicine
Course: Chinese medical science
Keywords: Parknson Liver Yang Deficiency The warm liver Zhichan capsules MAO-B Oxidative stress free radicals
CLC: R277.7
Type: Master's thesis
Year: 2008
Downloads: 34
Quote: 0
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Abstract


The article on the basis of diagnosis and treatment of inherited the instructors cover Guozhong Professor the liver Yang Deficiency clinical experience , more depth , systematic clinical and experimental study of PD patients with liver yang deficiency . Proposed : the PD disease located in the brain , but the disease is present in the liver , and for the first time proposed PD existence of a the Liver Yang Deficiency new argument , legislative warm liver Qi , junior Jieyu Huoxue . Chatter ended -by with warm liver capsule system clinical study of 16 cases of PD patients in the country for the first time to use the UPDS with CGI International Universal Scale , the results show : in Chinese medicine elderly chatter permit , UPDS assessment on Sinemet group The results were consistent in CGI, improve liver yang deficiency and somatic symptoms were significantly better than the control group of Sinemet . To demonstrate the efficacy mechanism of action , this study used the the PD rotation behavior , neurotransmitters , biochemical and other means , to observe the 6-OHDA -induced rotational behavior yang cortisone -induced rat model of intracerebral DA content of antioxidant , free radical scavenging , inhibition of brain MAO-B activity test . The results showed : temperature liver Zhichan capsule DA agonist or postsynaptic role indeed . It can significantly improve the content of DA the yang cortisone -induced rat model of brain . Aged mice reduced erythrocyte SOD , CAT , GSH-PX in the brain activity have increased the role , can significantly reduce the MDA and brain lipofuscin in aged mice plasma , and markedly inhibited the elderly of MAO-B activity of the brain of mice . And if guides have significantly increased the role of the small intestine of mice creep function . In summary , the temperature liver ended Shake the efficacy of the capsule mechanism is at least by anti-oxidation, free radical scavenging and inhibition of brain MAO-B activity and reduces the oxidation of the DA , protect DA neurons that functions as temperature further clinical application of liver Zhichan capsules provide a reliable experimental basis .

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CLC: > Medicine, health > Chinese Medicine > Chinese medicine practitioners of other disciplines > TCM neurology and psychiatry
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