Dissertation > Excellent graduate degree dissertation topics show

The Relationship between the Level of Monoamine Neurotransmitters and the Change of Ethology and Imageology after Nucleus Accumbence Lesioned in Morphine-addicted Rats

Author: LiPing
Tutor: FuXianMing
School: Anhui Medical University,
Course: Surgery
Keywords: morphine dependence stereotaxic techniques nucleus accumbens /injuries behavior imaging biogenic amine neurotransmitter
CLC: R651
Type: Master's thesis
Year: 2008
Downloads: 51
Quote: 0
Read: Download Dissertation

Abstract


ObjectiveTo investigate the relationship between the level of monoamine neurotransmitters and the change of ethology after nucleus accumbence lesioned in morphine-addicted rats,and observe the imageological changes in brain regin of morphine-addicted rats before and after stereotaxic lesion.MethodsAn acute morphine-addicted rat mode was made with morphine by abdominal cavity injection. The interval of the injection is 12 hours. The dose of injection was added by daily from 5 mg/kg to 90 mg/kg within 10 days. Before and after stereotaxic lesion, the level of monoamine neurotransmitters in different brain regions was detected by a fluorescence detector (high performance liuid chromatography). The relationship between the monoamine neurotransmitters and ethological changes was analyzed after nucleus accumbence lesioned in the experiment rats.Results(1) There was a high successful rate in making acute morphine-addicted rats, and remarkable ethological changes in morphine-addicted rats before and after stereotaxic lesion.(2)There were significant difference in ethological changes between nucleus accumbens-lesioned group and nucleus accumbens pseudo-lesioned group.(3)After nucleus accumbence lesioned, the abstinence syndrome could lessen. The levels of DA, NE, 5-HT in the regions of prefrontal cortex, hippocampus and ventral tegmental area were obvious changed compared with the unlesioned group in morphine-addicted rats (P<0.01).(4) Before and after lesion, the imageology of the morphine-addicted rats’brain are different too, the brain edma of the nucleus accumbence region were evidently.Conclusions(1)There may have some relationships between changes of ethology and the levels of monoamine neurotransmitters in the morphine-addicted rat.(2)Before and after lesion, the imageology of the morphine-addicted rats’brain are different too,the brain edma of the nucleus accumbence region were evidently.

Related Dissertations

  1. Synthesis and Characterization on Semi-Aromatic Polyamides Containing Benzoxazole Units,O633.5
  2. A Study of the Relevance of Social Behavior and Building Space,TU-024
  3. Study on the Boundary of the Behavior Space and Its Characteristic of Architectural Space,TU-024
  4. The Research on Ship Imaging Algorithm under the Sea Clutter Background,TN958
  5. Research on Infrared Image Simulation for Aerial Objects and Background,TP391.41
  6. 3D Visualization Research of Medicial Ultrasound Image,TP391.41
  7. Research on Millimeter Wave Imaging with Scanning Array,TP391.41
  8. Gui Design and Application Oriented to Embedded Ultrasonic Detecting System,TP274.53
  9. Scene Modeling for Simulation of Hyperspectral Remote Sensing System,TP72
  10. Research on the Behavior of Tourist from Russia to Sanya,C912
  11. Financing Behaviors of Sina Microblogging in View of Risks,F49
  12. Photoacoustic Signals Analysis and Its Medical Applications Based on Focused Scanning Photoacoustic Imaging,R318.51
  13. In East Guangdong Rural biology teacher behavioral development,G633.91
  14. Strategies on Encourage Students’ Classroom Participation in English Teaching in Primary School,G623.31
  15. The Relative Research on the Prosocial Behavior and the Perceived Social Support of the Left-in Junior Student,B844.2
  16. The Influence of Long-term Regular Exercise to the Distribution and Change Regulation on Human Skin Temperature,G804.2
  17. Analysis on Tea Consumer Behavior Characteristics and Marketing Strategies,F274
  18. Effects of Sodium Dificiency on Physiology and Behaviour in the Cotton Boll Worm, Helicoverpa Armigera (Lepidoptera: Noctuidae),S435.622.3
  19. The Clinic Value of Diffusion Weighted Whole Body Imaging with Background Body Signal Suppression (DWIBS) Compared with hPET/CT,R445.2
  20. HIV and Syphilis Infection and Risk Factors among Young Men Who Have Sex with Men,R512.91
  21. The Effects of Family Environment on Aggressive Behavior of Children in PE Course,G623.8

CLC: > Medicine, health > Surgery > Of surgery > Head and Neurosurgery
© 2012 www.DissertationTopic.Net  Mobile