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Objective: tumorigenesis and metastasis is a complex process, including adhesion, migration, and tumor cell invasion of the extracellular matrix. Tumor suppressor factor (PTEN) protein levels in tumor proliferation, differentiation, and matrix metalloproteinases (MMP-7) expression and tumor proliferative activity and tumor infiltration depth and the range of the lymph nodes, vascular endothelial growth factor ( VEGF) is the main angiogenic factors, can stimulate the proliferation of endothelial cells, increased microvascular permeability, and promote the formation of tumor blood vessels, and to provide conditions for rapid tumor proliferation and metastasis. Of PTEN, MMP-7 and VEGF in other tumors has been preliminary studies have not been reported in giant cell tumor of bone. The experiments discussed in giant cell tumor of PTEN, MMP-7, VEGF expression and clinical staging classification and recurrence and metastasis, gender relations. Method: select the pathological examination of 65 cases of giant cell tumor patients wax block, including 38 male and 27 female patients, mean age of 32.5 years. Recurrence and metastasis of giant cell tumor clinical and pathological staging classification and immunohistochemical assay specimens of PTEN, MMP-7, VEGF gene protein expression using SPSS12.0 statistical software, statistical data, analysis relationship. Results: PTEN, MMP-7, VEGF positive expression rate were 56.95%, 72.3%, 49.2%; positive expression rate of PTEN in the \trend, but the differences between groups not significant, P gt; 0.05; whereas MMP-7 positive expression rate, respectively, for 39%, 72.5%, 96%, of VEGF positive expression rate was 17.4%, 54.5%, 68%, and the difference between the two groups significantly, P lt; 0.05 (P = 0.031,0.001); metastasis group of PTEN, MMP-7, the positive expression rate of VEGF were 30%, 100%, 85%, in the non-transfer group PTEN, MMP-7 , VEGF in positive expression rates were 68.8%, 60%, 33.3%, the obvious difference between the two groups, P lt; 0.05 (P = 0.003,0.001,0.001); recurrent group of PTEN, MMP-7, VEGF positive expression rates were 33.3%, 86.3%, 86.6%, non-recurrent group of PTEN, MMP-7, of VEGF positive expression rates were 64%, 68%, 38%, the obvious difference between the two groups, P lt; 0.05 (P 0.035,0.006,0.01), and PTEN and MMP-7, of VEGF negative P lt; 0.05 pathological stage classification (P = 0.001,0.02), and age, no significant difference in gender. Conclusion: The occurrence and development of tumor is the result of multi-gene action of PTEN, MMP-7, VEGF expression \tumor's clinical assessment, clinical treatment choice prognosis has important clinical significance.
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