Dissertation > Excellent graduate degree dissertation topics show

The Clinical Significance of the Expression of Costimulatory Molecule PD-L1 in Transitional Cell Carcinoma of the Bladder

Author: KeZunJin
Tutor: ZengFuQing
School: Huazhong University of Science and Technology
Course: Surgery
Keywords: BTCC Programmed death ligand 1
CLC: R737.14
Type: Master's thesis
Year: 2007
Downloads: 20
Quote: 0
Read: Download Dissertation

Abstract


Objective To investigate the programmed death ligand -1 (PD-L1) expression and its clinical significance in bladder transitional cell carcinoma (BTCC) tissue . PD-L1 expression in the the bladder mucosal tissues using immunohistochemical staining (SP) method detected 59 cases of BTCC cancer tissue in patients with and 10 patients from the edge of the tumor 2cm outside , reverse transcriptase polymerase chain reaction (RT-PCR) detected 30 cases of BTCC patients cancer tissues and its expression in bladder mucosal tissues outside of 10 cases from the tumor edge 2cm the PD-L1mRNA in the open four cases from patients with bladder diverticulum intraoperative specimens were taken as a negative control . The correlation analysis and the relationship between the expression levels and clinicopathological parameters . Results from the tumor margin 2cm outside the bladder mucosal tissues and negative control group showed no significant expression of PD-L1 , BTCC organization Immunohistochemical detection of PD-L1 positive expression rate of up to 62.7% ( 37/ 59 ) , RT - the PCR detection of PD-L1mRNA the positive expression rate of 66.6% ( 20 / 30 ) . PD-L1 expression and tumor TNM stage and lymph node metastasis was significantly related (P lt; 0.05), but with the patient's age , gender, and tumor pathological grading without significantly related ( P gt ; 0.05) . Conclusion PD-L1 is highly expressed in bladder transitional cell carcinoma (BTCC) tissue may play a role in tumor development process , hopes to become a new target for immunotherapy of bladder cancer .

Related Dissertations

  1. Detection of modified nucleosides in urine of bladder transitional cell carcinoma and its biological behavior of,R737.14
  2. The Expression of Caspase-3 and Bcl-2 in Transitional Cell Carcinoma of Bladder and Their Significance,R737.14
  3. The Expression and Significance of DNA Mismatch Repair Gene hMLH1 in Transitional Cell Carcinoma of Bladder,R737.14
  4. Expression of Egr-1 Protein and Heparanase in Bladder Transitional Cell Carcinoma and Its Clinical Significance,R737.14
  5. The Expression of FHIT, P53 and Ki-67 in Bladder Transitional Cell Carcinoma and the Relationship between Them,R737.14
  6. The Expression of the Tyrosine Kinase B in Transitional Cell Carcinoma of Bladder Tissues and Its Clinical Significance,R737.14
  7. The Research on Expression and Associativity of Livin and Smac in Bladder Transitional Cell Carcinoma,R737.14
  8. The Expression and Clinical Significance of MMP-9, COX-2 and OPN in Transitional Cell Carcinoma of Bladder,R737.14
  9. The Expression and Significance of TfR in Bladder Transitional Cell Carcinoma,R737.14
  10. The Influence and Analysis of Chronic Obstructive Pulmonary Disease in Patients with Bladder Transitional Carcinoma,R737.14
  11. The Relationship between XPC Expression and Loss of Heterozygosity of Allele Loci on Chromosomes 9 and 17 in Bladder Cancer,R737.14
  12. Exon 2 Methylation Inhibits HEPACAM Expression in Transition Cell Carcinoma of the Bladder,R737.14
  13. Expression of HEPACAM and VEGF in Transitional Cell Carcinoma of the Bladder and the Effect of the HEPACAM Gene on the Expression of VEGF in Bladder Cancer Cell Lines,R737.14
  14. Glycosyl-phosphatidylinositol Anchored Interleukin-2 Expressed on Tumor-derived EXOSOMES Induces Anti-tumor Immune Response,R737.14
  15. The Expression and Significance of HER-2 and MGMT in Transitional Cell Carcinoma of Bladder,R737.14
  16. The Study of Association Expression of P27 and VEGF in Bladder Transitional Cell Carcinoma,R737.14
  17. The Expression and Significance of PLK1 and Cyclin B1 in Transitional Cell Carcinoma of Bladder,R737.14
  18. GATA6, ROR2 and STAT3 in bladder transitional cell carcinoma and its significance,R737.14
  19. BTCC preliminary study differential expression of microRNAs,R737.14
  20. Expression and Significance of PRDM1,PRDM2,PRDM5,PRDM14 in BC,R737.14
  21. With AAV vectors for RNAi in silence for the bladder cancer 5637 cells E2F3 gene Experiment,R737.14

CLC: > Medicine, health > Oncology > Genitourinary tumors > Urinary tumors > Bladder tumor
© 2012 www.DissertationTopic.Net  Mobile