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The herbal compound head wind the more Dripping Pills serum medicinal chemistry research

Author: FengZuoJuan
Tutor: ZhangYi
School: Chengdu University of Traditional Chinese Medicine
Course: Medicinal Chemistry
Keywords: Head wind the more Dripping Pills Pharmacodynamic Material Basis Serum Medicinal Chemistry Imperatorin Pharmacokinetic Fingerprinting Angelica
CLC: R284
Type: Master's thesis
Year: 2008
Downloads: 255
Quote: 2
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Abstract

The classic square head wind pain pills for the treatment of migraine, Angelica, Chuanxiong and green tea shamisen medicine, having Qufeng analgesic efficacy. The party to Angelica King and medicine, solution on tables scattered the wind, Tongqiao, pain; Chuanxiong as minister drugs, expelling wind and dampness, Huoxuezhitong; the green tea Qingshang and lowered, anti various drugs are too warm dry liter bulk so l have to drop, and for the drug. Head wind the more Dripping Pills head wind pain pills based on the development of new formulations. The preparatory work for rival wind more Dripping Pill preparations and pharmacodynamic studies is unclear, but its potential basis. The purpose: to more head wind Dripping Pills comparative study of the in vitro and in vivo ingredients as the starting point, the shift to the formation of sub-and metabolic processes in the body of the active ingredients in their blood, explore a head wind the more potential basis Dripping Pills, quality standards for the preparation improved scientific theory of compatibility explain the foundation. Method: 1. Application column chromatography, recrystallization, ^{1 H-NMR ^{13 C-NMR and other technical methods for the study of the chemical composition Fang Zhongjun drug Angelica. Application of the HPLC fingerprint technology rival wind more Dripping Pills fingerprint analysis. 3. HPLC fingerprint application, such as GC-MS technology rival wind more dripping pills serum medicinal chemistry research, based on blood shift form is divided into indicators pharmacokinetic study using the statistical software of DAS ver1.0 Fitting pharmacokinetic parameters. Results: 1 head wind the more Dripping Pills fingerprinting studies: rival wind the sore spot Fangzhong Jun drugs Angelica of ethyl acetate extract chemical composition separation, seven compounds, more head wind Dripping Pills fingerprints of qualitative analysis to provide corroboration. The more dropping pills HPLC fingerprint analysis method, compared head wind the more full side and Compound single flavor of herbs fingerprints to establish a stable and controllable head wind, its main component corresponding to Smell the vesting preliminary clarify head wind more the main component of the dripping pills, herbs Angelica number of accounts up Robinson medicine Chuanxiong second drug green tea at least. , Head wind more research Dripping Pills serum Medicinal Chemistry: HPLC fingerprint chromatography analysis method, more research administration head wind dropping pills in rat blood transitional ingredients and their sources of crude drug, found that the shift to the formation of sub-13, of which 11 prototype components, two metabolites, Angelica transitional components accounted for 10, consistent with his lord drug status, combined with the fingerprint of in vitro results proved the importance of head wind pain compatibility of science and Angelica prescription. And by GC / MS analysis method to head winds more dripping pills blood shift to form a sub-study, found that the shift to the formation of sub-4 have two prototypes ingredients. Head wind the more Dripping Pills pharmacokinetic studies in rats in vivo: pharmacokinetic study of analgesic active ingredient in a head wind the more Dripping Pill imperatorin prime indicators, establish a HPLC method for the detection of serum the Central European decursin vivo analysis. Determination of rats at different time points serum concentration of Europe decursin basis of the serum drug concentration - time curve, statistical software using DASver1.0 atrioventricular model fitting pharmacokinetic parameters results in line with a compartment open model, absorption double peak phenomenon, Tmax for 3h T _1/2 2.95h to 6.3h, MRT, Ka-6.087h ^{-1 , Ke 0.235h ^{-1 the AUC as 6.3 mg / L ^{* h. Conclusion: the more head wind Dripping Pills comparative study of the in vitro and in vivo ingredients as the starting point, head wind the more potential basis Dripping Pills by HPLC fingerprint, serum medicinal chemistry and drug pharmacokinetic studies, preliminary interpretation. Laid the foundation for the the standard scientific improvement of the quality of preparation and interpretation of the theory of compatibility. Dripping Pill-head wind the more innovative point of this research under the guidance of the theory of Chinese medicine as a whole concept, fully aware of the complexity of the research of traditional Chinese medicine, use of serum medicinal chemistry research ideas, combined from two angles vitro ingredient and the blood components study, is conducive to a more scientific to reveal Chinese herbal formula basis of their compatibility law. Separation of target components in vitro tracking to determine the basis of the effective substances, in vivo screening, fast, high hit rate, and the advantage of the role of the characteristics of the Traditional Chinese Medicine, a new study ways and means to clarify and carry forward the traditional Chinese medicine theory system.}}}}}

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