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The Research of the Chemical Constituents from the Bioactivity Part and the Quality Specification of Chuanmingshen

Author: SuZuoLin
Tutor: ZhangMei
School: Chengdu University of Traditional Chinese Medicine
Course: Medicinal Chemistry
Keywords: Chuanminshen Chemical composition Quality standards Pharmacological experiments
CLC: R284
Type: Master's thesis
Year: 2007
Downloads: 126
Quote: 0
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Abstract


Chuanminshen Chuanmingshen viloaceum Sheh et Shan. The Umbelliferae (Umbelliferae) Chuanminshen species, plant a single species endemic to China, Sichuan geoherbs. Lungs and phlegm, stomach, Sheng Jin, detoxification effect Chuanminshen attending Hyperactivity cough, fever Shangyin Ziyin to the drug. Apply to the tonic and strong body after the illness is a drug and Edible Plants. As the Sichuan geoherbs, both medicinal Chuanminshen consumption, the domestic market demand. But little chemical and pharmacological studies of the drug, but also the lack of a systematic and standardized. Quality control of herbs Chuanminshen only Sichuan Chinese Materia Medica Standards 1987 Simple Appearance Description 2005 edition of Chinese Pharmacopoeia has not yet received contained. In order to more fully develop the Sichuan valuable traditional Chinese medicine resources, and promote regional economic development, and to deepen the knowledge of the material foundation of Chinese medicines, looking for effective quality control indicators, and to lay the foundation for the development and utilization of the deep-seated this topic to Sichuan genuine medicine Chuanminshen as the research object, according to the theory of Chinese medicine, the guidance to Chuanminshen attending the function, the system chemical and pharmacodynamic study. Screening by chemical separation and pharmacodynamic comparison to the four pharmacological experiments (the ammonia induced cough experimental mouse tracheal phenol red excretion experiments, carbon particle clearance experiments and serum hemolysin experiments in) findings as the basis to determine the oil The ether fraction Chuanminshen antitussive and expectorant and immune pharmacodynamic active site. Repeatedly atmospheric column chromatography on silica gel isolated from the portion of eight compounds: palmitic acid (A), 2,6 - dimethoxy-benzoic acid (B), succinic acid (C), stigmastan alcohol (D), the rhubarb the phenols (E), 8 - hydroxy - 5 - methoxy complement bone pigment (F), vanilla acid (G), glucoside of stigmasterol (H). Wherein B, C, D, E, G, for the first time isolated from the plant obtained. On this basis, Chuanminshen medicinal quality standards a preliminary study. Of psoralen, 8 - hydroxy-5 - methoxypsoralen chrysophanol control, determined the herbs Chuanminshen TLC method; using UV spectrophotometry, medicinal herbs Chuanminshen total coumarin content determination method. The results of this research to The final to reveal Chuanminshen pharmacodynamic material foundation, improve its quality control methods, further expanding the range of clinical applications and drug development Chuanminshen laid the scientific foundation.

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