Dissertation > Excellent graduate degree dissertation topics show

An Evolutionary Model for Maximum Likelihood Alignment of DNA Sequences

Author: HeHua
Tutor: HuoHongWei
School: Xi'an University of Electronic Science and Technology
Course: Computer Software and Theory
Keywords: Bioinformatics Sequence alignment Evolutionary model Maximum likelihood Evolutionary parameters Parameter estimates
CLC: TP301.6
Type: Master's thesis
Year: 2008
Downloads: 104
Quote: 0
Read: Download Dissertation


Sequence alignment is an important research topic in the bioinformatics , function , structure and evolution of the sequence information is found . Many of the existing alignment algorithms are based on the objective function , the objective function substitution matrix and gap penalty contrast to the process and the results of scoring Hutchison score to determine the sequence alignment results , good or bad . The drawback of the algorithm based on the ratio of the objective function is little change in the scoring system may lead to dramatic changes in local or global alignment . Thus, the DNA sequence of the likelihood of the DNA sequence alignment algorithms for sequence alignment . This paper first describes the sequence than on the basic concept , detailed substitution matrix , gap penalty points and the objective function as well as their impact on sequence alignment , and in-depth study of the double sequence a variety of commonly used than the algorithm : dot matrix analysis , dynamic planning algorithm and a word or k- string method , and gives the algorithm thinking or pseudo- code . Then , according to the disadvantage of objective function - based algorithm , the proposed maximum likelihood matching algorithm, which is divided into two parts : parameter estimation algorithm and alignment algorithms . The likelihood ratio of the first to use the algorithm evolution parameter estimation algorithm parameters on one pair DNA sequence evolution valuation than estimated parameter values ??of the algorithm uses the DNA sequence . It is an independent , completely avoid the problem of DNA sequence similarity of different substitution matrix with suitable substitution matrices and gap penalty sequence alignment algorithm . Finally, the evolutionary model is verified through evolutionary model for maximum likelihood DNA sequence matching algorithm than than the results of the program results and FASTA comparison , the maximum likelihood DNA alignment algorithm correctness and accuracy.

Related Dissertations

  1. Compensation Methods of Different Speech Coding for Speaker Recognition,TN912.34
  2. Cloning and Expression Analysis of GPx, GST and SAHH Genes in Chlamydomonas Sp. ICE-L from Antarctica,Q943.2
  3. Based on statistics of the lognormal distribution heteroscedasticity model inferred,O212.1
  4. Gene Prediction and Sequence Analysis of Insect OBP CSP and sid-1,Q78
  5. Cloning and Molecular Analysis of Lovastatin Biosynthesis Related Genes from Monascus Purpureus,TQ927
  6. Identification of the Causal Organism of Soybean Bacterial Spots and Two Type Ⅲ Secreted Effectors’s Clone and Functional Analysis,S435.651
  7. Construction of an Est-Based Digital Northern Platform for Common Wheat Genes and Identification of Wheat Specific Genes Relative to Rice,S512.1
  8. Molecular Cloning, Sequence nad Expression Analyses of Two Transcription Factors ZmC4HC3 and ZmNAC,S513
  9. Mixed Exponential Distribution under Censored Accelerated test of quadratic estimates,O211.3
  10. Construction of Amino-Acid Substitution Matrix of Archaea Domain,Q936
  11. Research and Design of Electronic Equalization Based on Most Likelihood Sequence Estimation,TN911.5
  12. Research on Time Synchronization Algorithm in Wireless Sensor Networks,TN929.5
  13. Automated Fuzz Testing network protocol vulnerabilities mining method,TP393.08
  14. The Epidemiology of Torque-teno Canis Virusat One Suburb in Shanghai and Analysis of the Complete Genome,S858.292
  15. Extended Hidden Markov Models and Parameter Estimation Based on Genetic Algorithm,O211.62
  16. Cloning of Two Key Genes of Lignin Biosynthesis from Eucalyptus Spp and Functional Study,S792.39
  17. Research on Network Communication Signature Generation Technology of Trojan Horses,TP393.08
  18. Research on Shape Based Algorithm for Image Retrieval,TP391.41
  19. Research on the Ant Colony Algorithm Based on Pheromone Intensity and Its Application,TP301.6
  20. Functional Mapping of Quantitative Trait Loci in Forest Trees,S722
  21. Hereditary cataract gene mutation and protein functional changes,R776.1

CLC: > Industrial Technology > Automation technology,computer technology > Computing technology,computer technology > General issues > Theories, methods > Algorithm Theory
© 2012 www.DissertationTopic.Net  Mobile