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Studies on Supercritical Fluid Chemistry Reaction to Synthesis P-hydroxybenzoic acid
Author: ZhengZuoWu
Tutor: LiYan
School: Jinan University
Course: Process and analysis of food additives
Keywords: Hydroxybenzoate Supercritical chemical reaction Synthesis Koble-Schmitt reaction
CLC: TQ245.24
Type: Master's thesis
Year: 2000
Downloads: 245
Quote: 4
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Abstract
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Parabens are a class of broad-spectrum , efficient and safe preservatives . Due to low production in our country , is only used with the pharmaceutical industry . The low production of the root causes of its intermediate backward of hydroxybenzoic acid production process , low yield , and has not been improved and enhanced . At home and abroad hydroxybenzoic acid synthesis process gas - solid-phase method and suspension . These methods yield is low, generally below 45% , a long reaction time , energy consumption , complicated operation , but also pollutes the environment . This study is a supercritical carbon dioxide as a reaction medium and reactants synthetic -hydroxybenzoic acid. Has good solvent properties of supercritical carbon dioxide , the reaction mass and heat transfer have been greatly improved , so as to shorten the reaction time , reducing the stirring speed and improve the yield . This experiment investigated different carboxylation conditions hydroxybenzoic acid yield , and these conditions on Orthogonal Optimization ideal process as follows: the carboxylation pressure 8.5Mpa, time 60min, temperature 220 ??° C , stirring rate 400rpm . This experiment to improve the operation of acid precipitation in the original production process , the use of the segmented approach of acid precipitation , this method is beneficial by-product recovery of potassium sulfate, etc. , and to make our products to reduce the losses , purity improved . Acid analysis after the mother liquor can be recycled to reduce the number and difficulty of the sewage treatment . Hydroxybenzoate yield stability in the above process more than 80% . Test with this Law synthesis the solid catalyst phosphotungstic acid catalyzed esterification of hydroxy benzoic acid and ethanol , and use this common mold Aspergillus niger ethylparaben mildew performance evaluation results prove a highly effective fungicide .
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CLC: > Industrial Technology > Chemical Industry > Basic Organic Chemistry Industry > The production of aromatic compounds > Aromatic carboxylic acids and their derivatives > Aromatic acid functional derivatives > Fang ester
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