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Selection and Study on Toxicology, Pharmacodynamics of Yandureqing Liquid Injection for Chinese Veterinary Medicine

Author: ChenJiaJuan
Tutor: LiJianYong；JiaNing
School: Gansu Agricultural University
Course: Basic Veterinary Science
Keywords: Inflammation toxic hot Ching Filter Bacteriostatic Toxicology Pharmacodynamic
CLC: S853.7
Type: Master's thesis
Year: 2010
Downloads: 70
Quote: 0
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Abstract


Inflammation toxic hot \In this study, the inflammation toxic hot clear toxicology and pharmacodynamic discussed experimental and theoretical basis for its clinical application. Prescription and preparation process of screening tests, antibacterial test cylinder plate method. Results: \The most significant antimicrobial effect. Compound 1 to 6 Compound 6 inhibition significantly compared to the other compound. All Compound obvious effect on E. coli. Be seen the Compound F vitro antibacterial effect through in vitro antibacterial test. Toxicology tests, acute toxicity in mice results showed that the mice once orally 30g · kg-1 and intraperitoneal injection of 70g · kg-1 Shi observe the mice are all normal reactions after seven days no death. The long-term toxicity in rats, have three dose groups (10g · kg-1, 20g · kg-1, 30g · kg-1), intraperitoneal injection. The results show that (1) the impact of body weight of rats, female rats weight than the male influence, showed that the differences between male and female rats. (2) rat organ coefficient, 30g · kg-1, so that increased liver coefficient and kidney coefficients so that the thymus coefficient decreases. (3) check on rat hematological indices, the results showed that the test group indicators for each dose group with the control group showed no significant differences (P gt; 0.05) on inflammation drug the heat clearing injection liquid reached 30g · kg -1 · d-1 measured various hematological indices were not significantly affected. (4) the impact on blood biochemical parameters, the results showed that the test group dose group and control group difference was not statistically significant (P gt; 0.05); description of the Qing Yan toxic hot dose group some blood biochemical parameters in rats No clear impact. Pharmacology trials, anti-inflammatory tests using the mouse ear swelling model, the results showed that the inflammation toxic hot clear significantly inhibited xylene-induced mouse ear swelling; analgesic writhing test, the results show that the Qing Yan toxic hot can be reduced acetic acid writhing the writhing body test in mice, reducing thermal stimulation pain response in mice; the antipyretic test using the yeast fever model, results showed that the inflammation toxic hot clear 5g · kg-1 antipyretic effect compared with the model group and drug control group, there are obvious antipyretic effect; immune test results showed that the toxic hot Yan Qing to promote the role of the monocyte-macrophage phagocytic ability, no effect on the immune organ index and high dose groups can promote immune cytokines IL-2 levels increase of INF-γ, TNF-α content was no significant change. Can be seen from the above experimental results, inflammation toxic hot Qing group is reasonable, with minimal toxicity, anti-bacterial, anti-inflammatory, antipyretic, analgesic effect.

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CLC: > Agricultural Sciences > Livestock, animal medicine,hunting,silkworm,bee > Animal Medicine ( Veterinary Medicine) > Chinese veterinary science > Veterinary Pharmacology
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