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Epidemiological Study on Some factors Associated with Rheumatoid Arthritis

Author: ShenChong
Tutor: YeDongQing
School: Anhui Medical University,
Course: Epidemiology and Biostatistics,
Keywords: Antigen peptide processing transporter TAP Haplotype rheumatoid arthritis RA polymerase chain reaction - restriction fragment length polymorphism PCR-RFLP
CLC: R593.22
Type: Master's thesis
Year: 2001
Downloads: 106
Quote: 0
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Abstract


Objective To investigate the Han nationality in Anhui antigen peptide handling transporter (TAP) allele polymorphism and its correlation with rheumatoid arthritis (RA) . By the hypotonic hemolysis extraction of DNA in human blood leukocytes use of polymerase chain reaction - restriction fragment length polymorphism (PCR-RFLP) method ( in which the three - point primer mismatch ) and polyacrylamide gel electrophoresis method , TAP allele polymorphism analysis of 50 RA patients and 50 healthy control blood samples , looking for RA susceptible and resistant genotypes . The results of the TAP2 665-A and 565-A in the RA group was significantly lower than the control group ( P = 0.000 ) . RA group TAP2 379-V ,687-S ,665-T and 565 -T the four allele frequency was significantly higher than that in the control group ( P <0.05 ) ; the RA group 379 - II (8 % ) 637-GG (8%) was significantly lower than the control group ( P <0.05 ) . TAP2-665, 565 in RA group mainly homozygous TT (62%, 70%) was significantly higher than that in the control group ( P = 0.000 ) ; while the control group are AA (80%, 78%) - based and significantly higher than the RA group ( P = 0.000 ) ; the RA group TAP2D, TAP2E, TAP2I and TAP2K were significantly higher than that of the control group (P <0.05); outside and save TAP2K the corresponding Pc are less than 0.05 , indicating that TAP2D TAP2E and TAP2I may be risk factors for RA . Alleles haplotype TAP2B , TAP2J and TAP2L frequency in the RA group was significantly lower than the control group (P <0.05) for RA may have a protective effect , and the Pc of the latter two values ??were less than 0.05 . In addition to the common elsewhere in the crowd polymorphism characteristics , a conclusion Han nationality in Anhui TAP allele also has its own characteristics different from other parts of the race . Han nationality in Anhui exist KA susceptible and resistant TAP allele .

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CLC: > Medicine, health > Internal Medicine > Systemic disease > Autoimmune diseases > Autoimmune diseases, connective tissue disease > Rheumatoid arthritis
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