Dissertation > Excellent graduate degree dissertation topics show

The Effect of 125I Radioactive Seeds Implantation Upon Peripheral Nerves

Author: TianHao
Tutor: WuLeBin;LiZhenJia
School: Taishan Medical College
Course: Medical Imaging and Nuclear Medicine
Keywords: 125I radioactive particles Action potential Conduction velocity Potential amplitude
CLC: R817.4
Type: Master's thesis
Year: 2007
Downloads: 27
Quote: 0
Read: Download Dissertation

Abstract


Objective animal experiments , research 125I radioactive seed implantation low dose rate continuous exposure to peripheral nerve tissue nerve conduction and electrophysiological activity , and histological evaluation of the peripheral nerve tissue damage . ( 1) the establishment of model selected 32 healthy New Zealand rabbits , two of radioactivity the 125I radioactive particles of 0.9mCi by surgical implantation of healthy New Zealand rabbits left leg next to the sciatic nerve , the two non-radioactive 125I radioactive particles implanted next to the sciatic nerve of the right leg of the same group of rabbits , respectively, for the experimental group and the control group . Regular feeding . (2) the measurement and analysis of the action potential 5 days , 7 days , 10 days, 20 days , respectively , to take the the rabbits measurement bilateral leg 125I radioactive seed implantation parts of the sciatic nerve compound action potential afferent nerve action potentials and efferent action potential . The measure was the action potential amplitude and conduction velocity . Analysis comparing the experimental group and the control group of three sets of action potential difference at each time point as well as experimental and the control group at different time points of difference . Evaluation 125I radioactive particles peripheral nerve fiber action potentials . Results at each time point after 125I radioactive seed implantation , the experimental group and a control group of rabbits leg movement is not affected. Starting from 5 days point in time , the experimental group , the composite nerve afferent nerve action potential amplitude and conduction velocity decreased significantly. Efferent nerve action potential amplitude and conduction velocity at each point in time there is no statistical difference . The electron microscope can be seen as the point in time after the shift , the stepwise increase the myelin nerve tissue damage . Conclusion 125I radioactive particles through the release of gamma -ray and X-ray , close to continuous low-dose irradiation nerve tissue , the irradiation nerve fiber myelin degeneration distorted rupture, the peripheral afferent nerve fiber action potentials and the composite nerve fibers action potential conduction velocity and amplitude reduce the transmission of nerve impulses blocked, without affecting the peripheral nerve conduction velocity and potential amplitude of the outgoing fiber . This indicates that the the 125I radioactive particles organizations interstitial implantation of tumor can not only inhibit tumor growth , reducing tumor volume , while cancer pain relief , improve the patient 's quality of life .

Related Dissertations

  1. Effect of Swimming in Cold Water on Function and Structure of Peripheral Nerve in Diabetic Rats,R587.1
  2. Study on Biomarkers for Chronic Peripheral Neurotoxicity of N-hexane,R131
  3. Docosahexaenoic acid on rat ventricular myocytes electric physiological role and antiarrhythmic mechanisms,R965
  4. A Study of the Histologic Lesion Variability by the 125-iodine Radion Implanted of Hepatoma and Normo-liver,R735.7
  5. Clinical Study of Treating Diabetic perip-Heral Neuritis With Acupuncture and Herbs Immersing,R587.1
  6. Clinical Observation of Diabetic Perip-Heral Neuropathy Treated by Warm Needling Method,R246
  7. The Motor Nerve Conduction Velocity (MCV) of Diabetic Peripheral Neuropathy (DPN) Was Changed by Boosting Qi and Nourishing Yin, Quickening the Blood and Transforming Stasis,R259
  8. The Clinical Study on the Effect of Boosting Qi and Nourishing Yin, Quickening the Blood and Transforming Stasis to SNCV of Patients with DPN,R259
  9. The impact of exercise training on diabetic neuropathy in rats,R587.1
  10. Channels in Dorsal Root Ganglion Neurons Moe Key Lab of Modern Toxicology Nanjing Medical University,R285
  11. The Experiment about the Effect of the Acup-Uncture plus heat on the Nerve Growth Factor in the Chrpmoc Alcoholic peripheral neuropathy Rats,R245
  12. The Analysis for Response Signal of Rats Primary Visual Cortex V1 under the Visual Stimulation,TN911.6
  13. Application in Chronic Inflammatory Demyelinating Polyradiculoneuritis with Contact Heat Evoked Potentials,R745.43
  14. A Study of the Relationship Which is between the Clinical Situation and Ulnar Nerve Partly Changed in the Cubital Tunnel Syndrome,R688
  15. Study on Compound Muscle Action Potential of the Peroneal Nerve in Diabetic Peripheral Neuropathy,R587.2
  16. Conduction Failure of C Fibers in Diabetic Neuropathic Rats,R587.2
  17. The Efficacy and Mechanisms of Methylcobalamin and Lipoic Acid in the Treament of Type 2 Diabetes Pweripheral Neuropathy,R587.2
  18. The Study of Electrophysiological Characteristic and Action Potential in Cardiac Ventricle Muscle,R331
  19. The Function and the Possible Mechanism of Tongluotangtai Poly-pharmaceutical on How to Regulate and Influence the Experimental DPN Rats’ Neuro-function,R285.5
  20. Tongluo Sugar Thai side of diabetic peripheral neuropathy in serum IL-6 levels of expression of,R285.5

CLC: > Medicine, health > Of Medical > Radiation Medicine > Application of radioisotopes in medicine > Application in the diagnosis
© 2012 www.DissertationTopic.Net  Mobile