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The novel antiviral Pleconaril the synthesis research

Author: ZhaoYanFang
Tutor: GongPing
School: Shenyang Pharmaceutical University
Course: Medicinal Chemistry
Keywords: antiviral agents Pleconaril synthesis polymorphs
CLC: R914
Type: Master's thesis
Year: 2001
Downloads: 158
Quote: 1
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Abstract


The characteristics of virus and the development of antiviral agengts were briefly described in this paper, and the mechanism of a new broad -spectrum Picomavirus Inhibitors-Pleconaril was also introduced. The synthesis of Pleconaril was studied. A new synthetic route was designed and modified, which make easier to process, and the yield was elevated. The total yield of Pleconaril was 37.4%, which was synthesized from 2,6-dimethyl-4-hydroxyphenol by ten steps, including the preparation of side chains. Its structure was confirmed by IR, 1H-NMR, ?C-NMR, MS. The polymorphs of Pleconaril was also studied in different solvents.

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CLC: > Medicine, health > Pharmacy > Drug basic science > Medicinal Chemistry
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