Dissertation > Excellent graduate degree dissertation topics show

Study of Immediately Loaded Micro-implant’s Anchorage Stability in Hyperthyroid Rat Model

Author: BiJianLing
Tutor: LiJinYuan；ZhangBin
School: North China Coal Medical
Course: Clinical Stomatology
Keywords: Hyperthyroidism Thyroid hormone Micro - implant anchorage Immediately loaded Osseointegration rate
CLC: R581.1
Type: Master's thesis
Year: 2010
Downloads: 52
Quote: 0
Read: Download Dissertation

Abstract


Objective To establish a rat model of hyperthyroidism (hyperthyroidism), observed instantly load the micro implant hyperthyroid rat model of displacement and rate of osseointegration explore immediately loaded implant in a rat model of hyperthyroidism feasibility of micro, theoretical and experimental basis for patients with hyperthyroidism clinical orthodontic micro implant anchorage design. Materials and Methods 20 healthy adult female Wistar rats, weighing 200 ± 8 g. Randomly divided into two groups: hyperthyroidism group and the control group. The hyperthyroidism group of rats with euthyrox 60μg / (100g · d) orally. Control rats with saline 1ml / (100g · d) orally. After 28 days, the use of the inner canthus venous plexus blood collection blood were measured by serum T3, T4, to determine rat hyperthyroidism animal model success. Model implants in two groups of rats left tibia were shot for the X-ray observation of the implant in the tibial implant position and height of the bone edge, check implant loosening degree measurement implant the distance between, and instantly make the implant to the nickel-titanium Lahuang sustained load 100g Rally, the rats were sacrificed 30 days. In rats were killed 14 days before and 13 days, four days, three days, respectively, with tetracycline hydrochloride and calcein bone formation markers. Rats were killed after the acquisition the rat maxillary and bilateral tibial. The determination of the maxilla and right tibia bone mineral density and correlation analysis. The left tibia with implants: shoot X-ray observation of changes of the bone around the implant location and implant in the tibia, check the implant loosening degrees; measuring implant distance; production of bone tissue grinding, fluorescence observation toluidine blue staining of bone contact rate. The experimental data for statistical analysis. Results of a general hyperthyroid rats symptoms meet the clinical features of hyperthyroidism. Two groups of rats micro-implant anchorage loose and fall off, the micro-implant soft tissue around the infection. After the completion of the implant surgery, X-ray results show good implant position of the implant in the tibia, two implants close parallel; the implant load at the end, the results of the X-ray transmissive area around the implant, and Compared implant surgery is complete, no significant changes in the height of the edge of the implant in the tibia bone. The animal model ig 28 days hyperthyroidism group and the control rats, serum T3, T4 difference was statistically significant (P lt; 0.01). Compared with the control group, hyperthyroidism group, serum T3, T4 significantly increased, suggesting that rats in hyperthyroidism state modeling success. Bone mineral density in hyperthyroidism group rat mandible and tibia bone density correlation coefficient r = 0.879 (P lt; 0.01), are highly correlated, control rats jawbone and tibial bone density correlation coefficient r = 0.915 (P lt; 0.01), are highly correlated. The distance between the displacement measurement load the initial and final micro-implant anchorage difference was statistically significant (P lt; 0.01), two groups of micro-implant anchorage displacement. The hyperthyroidism group of micro-implant displacement greater than the control group (P lt; 0.05). 5 fluorescent histology observed in control group showed significant double labeling with fluorescence mainly in the trabecular bone surface and the implant - bone interface; compared with the control group, hyperthyroidism group stronger fluorescence labeling, the distance between the double-labeled with obviously enlarged (P lt; 0.01), marked mainly concentrated in the trabecular bone surface and the implant - bone interface, part of the trabecular bone surface was eroded like. The hyperthyroid group bone mineral apposition rate was higher (P lt; 0.01). Bone contact rate the hyperthyroidism group of bone contact rate higher than that in control group (P lt; 0.01). Conclusion 1 hyperthyroidism group and the control group showed consistent micro implant is more stable, no loose and fall off, and showed good biocompatibility, the hyperthyroid rat micro-implant anchorage instantly load is feasible. 2 hyperthyroidism group and the control group of micro implant is not absolute anchorage afterburner after implant displacement. Hyperthyroidism, increased displacement of the micro-implant anchorage. Hyperthyroidism group of bone contact rate was higher, suggesting that promote peri-implant bone formation in the implanted early thyroid hormone.

Related Dissertations

  1. The Clinical Analysis between the TCM Syndromes of Subacute Thyroiditis (Hyperthyroidism Stage),R259
  2. Relationship between the Severity of Heart Failure and Alteration of Serum Thyroid Hormone Concentration and Peripheral Blood Leukocyte Count in Acute Myocardial Infarction Patients,R542.22
  3. The Combined Treatment of Complex Adult Angleclass Ⅱ Division 1,R783.5
  4. Ultrasound of new technologies on hyperthyroidism cause heart and liver damage evaluation,R581.1
  5. Type 2 the deiodinase Thr92Ala polymorphism with hyperthyroid heart disease related research,R541.85
  6. Effect of Ammonium Perchlorate on Iodine Uptake and Antioxidant Capacity of Thyroid,R114
  7. The Research on the Changes and Prognosis of Thyroid Hormone Levels in Critically Ill Patients,R459.7
  8. Effect of Hyperthyroidism on the Expression of Synaptotagmin-1 in the Prefrontal Lobe of Adult Rats,R581.1
  9. Patients with essential hypertension and serum thyroid hormone changes in the relationship with lipid,R544.1
  10. Liver Xiehuo, Endometriosis Treatment of Strong Anger-based Clinical Effect of Hyperthyroidism,R259
  11. Effects of Subchronic Low-dose TCDD on Thyroid Morphology and Function with Adult or in Utero/Lactation Exposure in Rats,R114
  12. The Role of Thyroid Hormone and Its Receptor TRβ Gene Mutation in Pathogenesis and Prognosis of Thyroid Cancer,R736.1
  13. Analysis of Factors Associated with Causes of Death in Inpatients with Thyroid Dysfunction,R581
  14. Quantitative Analysis of Color Doppler Flow Signals Treatment of Hyperthyroidism in the Evaluation of Value,R581.1
  15. The Survey Research on Hyperthyroidism’s Psychological Health of Diverse Personalities,R395
  16. The Research on Therapy of Mourishing the Heart and Tranquilization in Treating Hyperthyroidism,R259
  17. Clinical Analysis of Pregnancy Complicated with Hyperthyroidism,R714.2
  18. Changes in Cardiovascular Functiions in Thyroxine-Induces Hypertension,R581.1
  19. The Correlative Analysis between Catch-up Growth and Weight Cycling Following Treatment of Hyperthyroidism,R581.1
  20. Study of Thyroid Hormone Levels in Patients with Hyperthyroidism Who Received Only 131I Therapy and Glucocorticoid Following 131I Therapy,R581.1

CLC: > Medicine, health > Internal Medicine > Endocrine diseases and metabolic diseases > Thyroid disease > Hyperthyroidism
© 2012 www.DissertationTopic.Net  Mobile