|
Obesity (obesity) in the role of genetic and environmental factors, the body's energy intake is greater than the consumption of energy in the form of fat stored in the body, resulting in excessive weight gain caused by nutritional imbalance disease. Obesity has become a global epidemic. Obese people have an increased risk of diabetes and cardiovascular disease. Metabolic syndrome (metabolic syndrome, MS) refers to a series of metabolic disorders in the same individual aggregation phenomena, including: abdominal obesity, dyslipidemia, glucose regulation and hypertension. Metabolic syndrome is a risk factor for diabetes and cardiovascular disease. Third of the U.S. National Health and Nutrition the survey (NHNES III) (1988 to 1994) data show that 12 to 19-year-old general population prevalence of MS was 4.2%, overweight and obesity were 6.8% and 28.7%, respectively, of normal weight only 0.1% of the population. Although the pathogenesis of the metabolic syndrome is unclear, it is clear that obesity is one of the risk factors of the metabolic syndrome. Adipose tissue can be stored not only the energy can also secrete a variety of biologically active adipokines. Leptin (leptin LEP) and adiponectin hormone (adiponectin, ADIPO) that is secreted by fat cells adipokines. ob / ob mice due to lack of leptin performance obesity, administration of exogenous leptin, decrease of food intake and increased energy consumption, weight decreased; subsequent study found the most obese leptin in the blood content of normal weight. ratio is increased, it does not appear to weight loss. The studies have shown that leptin can act on the fat, muscle, liver, blood vessels, and loaded with tissue and involved in lipid metabolism, blood pressure regulation, may be provided and the occurrence of metabolic syndrome. The adipokines adiponectin is secreted by fat cells, and the same adipokines leptin and adiponectin in the blood of obese relative to normal weight is reduced. Currently involved in glucose regulation of fat metabolism, increase insulin sensitivity, may be related to the occurrence and the metabolic syndrome. The cause of leptin, adiponectin is metabolic syndrome is unclear. The conclusion is inconsistent correlation of leptin, adiponectin and metabolic syndrome components. Adolescence is a period of high incidence of childhood obesity, adolescent obesity is also easy to extend for adult obesity and children than adults less complicated by diabetes, cardiovascular disease, more leptin, adiponectin and metabolic syndrome components sexual performance. In this study, adolescent children for the study, leptin, adiponectin and metabolic syndrome pathogenesis of metabolic syndrome and early prevention provide a theoretical basis. The purpose of understanding in obese children, blood sugar, blood lipids, blood pressure, leptin, adiponectin levels. Explore the relationship between leptin, adiponectin and metabolic syndrome. Subjects and methods were selected 177 of the 13 to 15-year-old adolescent children, obesity 86, male 45, female 41; those of normal weight, 91, male 51, female 40. Height (height), weight (weight), the waist (waistcircumference, WC), hip (hip Circumference), systolic blood pressure (systolic blood pressure, SBP) and diastolic blood pressure (diastolic blood pressure, DBP), calculate the body mass index ( body mass index, BMI) and waist-to-hip ratio (waist-to-hip ratio, WHR). The extracted morning fasting blood glucose (glucose, GLU), triglyceride (triglyceride, TG) and high density lipoprotein cholesterol (High-density-lipoprotein-cholesterol, HDL-C), radioimmunoassay ( radioimmunoassay, RIA) serum insulin (insulin, INS) and leptin, enzyme-linked immunosorbent assay (enzymelinked immunosorbent assay, ELISA) serum adiponectin. Diagnosis of the metabolic syndrome using the modified American scholar Cook adolescents MS diagnostic criteria. Numerical variables were compared using the t test and one-way ANOVA, bivariate correlation analysis pearson correlation and partial correlation analysis for categorical variables, the chi-square test, obese children with metabolic syndrome risk factors using logistic regression analysis. Results 1 male obese group triglycerides, systolic blood pressure, insulin, leptin average higher than the normal weight group, high-density lipoprotein cholesterol and adiponectin levels below the normal weight group (TG: 1.74 ± 0.91 mmol / l and 0.76 ± 0.22mmol / l: SBP: 123.60 ± 14.11mmHg and 111.38 ± 10.18 mmHg; INS: 28.72 ± 13.79mIU / L and 16.74 ± 6.53 mIU / l; LEP: 19.49 ± 6.94μg / l and 8.08 ± 4.15μg / l ; HDL-C: 1.07 ± 0.25 mmol / L and 1.36 ± 0.33 mmol / l; the Adipo: 3.50 ± 1.50mg / l and 5.28 ± 2.68mg / l, P <0.05). Female obese group triglycerides, systolic blood pressure, diastolic blood pressure, insulin and leptin levels higher than the normal weight group, high-density lipoprotein cholesterol and adiponectin levels below the normal weight group (TG: 1.43 ± 0.64mmol / l and 0.91 ± 0.25 mmol / l; SBP: 115.48 ± 10.47mmHg and 105.95 ± 9.71mmHg; DBP: 73.73 ± 8.84 and 66.53 ± 8.53; INS: 24.51 ± 10.93 mIU / l and of 17.12 ± 5.45mIU / l; LEP: 27.55 ± 4.23μg / l and 17.93 ± 5.08μg / l: HDL-C: 1.13 ± 0.23 mmol / l and 1.48 ± 0.33 mmol / l; the Adipo: 4.66 ± 3.06mg / l and 6.33 ± 3.64mg / l, P <0.05). The obese children metabolic syndrome detection rate of 30.23%, higher than normal-weight children (P <0.01). 2 serum leptin levels in obese group and normal weight men were lower than women (obese group: 19.49 ± 6.9μg / l and 27.55 ± 4.23μg / l, control group: 8.08 ± 4.15μg / l and 17.93 ± 5.08μg / l , P <0.01); serum adiponectin levels in obese group and normal weight men were lower than women (obese group: 3.50 ± 1.50 mg / l and 4.66 ± 3.06 mg / l, the control group: 5.28 ± 2.68 mg / l and 6.33 ± 3.64 mg / l, P <0.05). Leptin and BMI, waist circumference, insulin, triglycerides, systolic blood pressure was positively correlated (BMI: M r = 0.722, female r = 0.812; WC: M r = 0.778, the woman r = 0.796; INS: M r = 0.625, female r = 0.438; TG: M r = 0.576, r = 0.389; SBP: M r = 0.415, female r = 0.359, P <0.05), diastolic blood leptin and women were positively correlated (r = 0.395, P < 0.05), leptin and high-density lipoprotein cholesterol showed a negative correlation (M r = -0.347 and the woman r = -0.535, P <0.05); control BMI, leptin and men only insulin positive correlation (partial correlation coefficient = 0.402, P <0.05), with men and women triglycerides, high-density lipoprotein cholesterol, systolic blood pressure, diastolic blood pressure were not correlated (P> 0.05). 4 adiponectin and BMI, waist circumference, insulin, triglycerides were negatively correlated (BMI: M r = -0.350, the woman r = -0.299; WC: M r = -0.405, female r = -0.317; INS: M r = -0.232, the woman r = -0.327; TG: M r = -0.301, female r = -0.240, P <0.05), and high-density lipoprotein cholesterol was positively related (M r = 0.251, the woman r = 0.260, P < 0.05); After controlling for BMI, adiponectin and triglycerides, high-density lipoprotein cholesterol, insulin had no correlation (P> 0.05). BMI and triglycerides, systolic blood pressure, diastolic blood pressure, insulin was positively correlated (TG: M r = 0.664, female r = 509; SBP: M r = 0.532, female r = 0.562; DBP: M r = 0.24, female r = 0.513; INS: M r = 0.504, female r = 0.545, P <0.05), and high-density lipoprotein cholesterol was negatively correlated (M r = -0.419, female r = -0.599, P <0.05); leptin control , adiponectin partial correlation analysis, BMI, triglycerides, systolic blood pressure, diastolic blood pressure, high density lipoprotein cholesterol is still relevant (TG: male, partial correlation coefficient = 0.407, the female partial correlation coefficient = 0.364; the SBP: Male partial correlation coefficient = 0.368, the female partial correlation coefficient = 0.509; DBP: M partial correlation coefficient = 0.218, female partial correlation coefficient = 0.393: HDL-C: M partial correlation coefficient = -0.259, the female partial correlation coefficient = -0.337, P are <0.05). Control leptin partial correlation analysis, female BMI and insulin (partial correlation coefficient = 0.435, P <0.05), male BMI and insulin (P> 0.05). Obese children with metabolic syndrome risk factors logistic regression analysis showed that BMI, insulin in obese children risk factors of the metabolic syndrome (BMI: OR = 1.974; INS: OR = 1.884, P <0.05). Conclusions puberty obese children in abnormal lipid metabolism, blood pressure, serum leptin, insulin levels increased and adiponectin levels decreased, obese children with metabolic syndrome detection rate increased. 2 adolescent children between serum leptin and triglycerides, systolic blood pressure, diastolic blood pressure was positively correlated with high-density lipoprotein cholesterol was negatively correlated; adiponectin and triglycerides were negatively correlated, high-density lipoprotein cholesterol was positively correlated; obesity children, elevated serum leptin, adiponectin decreases may be related to a higher incidence of metabolic syndrome. 3 serum leptin and insulin levels were positively correlated; leptin may be one of the main factors that caused adolescent male children, elevated serum insulin. 4 degree of obesity, fasting serum insulin levels are a risk factor for metabolic syndrome in obese children.
|